| Japanese |
|---|
| Title | 代謝性アシドーシスにおけるドパミン, ドブタミンの心筋収縮性に及ぼす効果 |
|---|
| Subtitle | |
|---|
| Authors | 劔物修*, 田中亮* |
|---|
| Authors(kana) | |
|---|
| Organization | *北里大学医学部麻酔科 |
|---|
| Journal | 循環制御 |
|---|
| Volume | 4 |
|---|
| Number | 1 |
|---|
| Page | 135-140 |
|---|
| Year/Month | 1983/ |
|---|
| Article | 原著 |
|---|
| Publisher | 日本循環制御研究会 |
|---|
| Abstract | 「要旨」ネコの摘出右室乳頭筋標本を用い, ドブタミン, ドパミンの心筋に対する直接的効果を正常状態(pH=7.40)および代謝性アシドーシス状態(pH=7.00)において比較検討した. 等張性収縮と等尺長収縮を観察し, 最大短縮速度(Vmax), 最大発生張力(Fm), 最大張力発生速度(maximal dF/dt)につき両薬物の10-7Mから10-4Mまでの7段階の濃度で比較した. 両薬物とも正常状態およびアシドーシス状態において量依存性の陽性変力効果が認められた. アシドーシスでの効果が正常状態に比較して軽度であった. アシドーシス自体で抑制される心筋収縮性はドパミン5×10-7M, ドブタミン3×10-7Mで拮抗された. アシドーシスでの両薬物の陽性変力効果は十分期待されるが, アシドーシスの補正も重要であることが示唆された. |
|---|
| Practice | 基礎医学・関連科学 |
|---|
| Keywords | |
|---|
| English |
|---|
| Title | Comparative effects of dopamine and dobutamine on contractile state of myocardium in metabolic acidosis |
|---|
| Subtitle | |
|---|
| Authors | Osamu Kemmotsu, Ryo Tanaka |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Anesthesiology, Kitasato University School of Medicine |
|---|
| Journal | Circulation Control |
|---|
| Volume | 4 |
|---|
| Number | 1 |
|---|
| Page | 135-140 |
|---|
| Year/Month | 1983/ |
|---|
| Article | Original article |
|---|
| Publisher | Japan Society of Circulation Control |
|---|
| Abstract | Metabolic acidosis decreases contractile performance of myocardium and responsiveness of heart to catecholamines. This may play an important role in treating patients in shock with metabolic acidosis. This study was designed to compare the effects of dopamine and dobutamine on the contractile state of isolated cat papillary muscles in normal state (pH=7.40) with those in experimentally produced metabolic acidosis (pH=7.00). Four equal group of muscles were studied (total 28 muscles) :a) dopamine, b) dobutamine in normal state, c) dopamine, d) dobutamine in metabolic acidosis. Dopamine or dobutamine was added into bathing solution in 7 different molar concentrations : 10-7M, 3x10 -7M, 10-6M, 3x10-6M, 10-5M, 3x10-5M and 10-4M. Dose-dependent positive inotropic responses were assessed both in normal and metabolic acidosis. The per cent increses in Vmax at 10-6M were 32 in normal state and 22 in metabolic acidosis. At 10-6M dobutamine, these values were 40 and 27, respectively. Changes in Fm and maximal dF/dt were similar to those observed with Vmax. |
|---|
| Practice | Basic medicine |
|---|
| Keywords | dopamine, dobutamine, contractile state, myocardium, metabolic acidosis |
|---|