| Japanese |
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| Title | Enflurane/N2O麻酔における各種交感神経作動薬の心機能, 心筋酸素需給バランスに及ぼす影響 |
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| Subtitle | |
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| Authors | 仲田房蔵*, 劒物修*, 田中亮* |
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| Organization | *北里大学医学部麻酔科 |
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| Journal | 循環制御 |
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| Volume | 4 |
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| Number | 3 |
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| Page | 487-493 |
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| Year/Month | 1983/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「要旨」Enflurane/N2O(GOE)と各種交感神経作動薬の相互作用について, 心収縮時相(STI)を計測しPEP/LVET比を心機能の指標とし, STIと血圧測定からDPTI/TTI比を算出し, 心筋酸素需給バランスの指標として比較検討した. ASA-Iに相当する手術予定患者43名をGOEで緩速導入後, methoxamine 2mg, ephedrine 10mg, Effortil 2mg, Carnigen 1ml, dobutamine 5μg/kg/minを投与し, GOEのもとでのこれらの薬物の影響を検索した. GOEによる心機能の抑制はmethoxamine Tは改善されず, ephedrine, Effortilではその改善は不十分であり, Carnigen, dobutamineで改善された. 心筋酸素需給バランスはいずれの場合にも保持された. 非観血的方法によるPEP/LVET比, DPTI/TTI比の観察は, 麻酔中の心循環系の管理のうえに有用と考えられた. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Non-invasive assessments of cardiac function and myocardial oxgen balance during enflurane/N2O anesthesia : Effect of various sympathomimetic agents |
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| Subtitle | |
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| Authors | Fusazo Nakata, Osamu Kemmotsu, Ryo Tanaka |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Kitasato University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 4 |
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| Number | 3 |
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| Page | 487-493 |
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| Year/Month | 1983/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Non-invasive assessment of cardiac function and myocardial oxygen balance of various sympathomimetic agents, utilizing computerized STIs (systolic time intervals) measurement, were performed during enflurane/N2O (GOE) anesthesia in 43 good-risk (ASA-1) surgical patients. PEP/LVET (the ratio of pre-ejection period and left ventricular ejection time) as an index of cardiac function and DPTI/TTI (the ratio of diastolic pressure time index and tension time index) as an index of myocardial oxgen balance were evaluated during GOE anesthesia and following administrations of methoxamine, ephedrine, Effortil, Carnigen and dobutamine. Increased PEP/LVET, means depression of cardiac function, by GOE was improved by all sympathomimetic agents except methoxamine. However, improvements of GOE-depressed cardiac function was not enough with ephedrine and Effortil. DPTI/TTI was either increased or unchanged during GOE anesthesia. These date indicate that Carnigen and dobutamine are more effective agents than ephedrine and Effortil for restoration of depressed cardiac performance by GOE anesthesia and that myocardial oxgen balance based on DPTI/TTI is well maintained with improvement of cardiac function by β-stimulation of sympathomimetic agents during GOE anesthesia. |
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| Practice | Basic medicine |
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| Keywords | non-invasive assessment, cardiac function (PEP/LVET), myocardial oxgen balance (DPTI/TTI) , enflurane/N2O anesthesia, sympathomimetic agents |
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