| Japanese |
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| Title | 吸入麻酔薬とカルシウム拮抗薬の心筋収縮性に及ぼす相互作用 |
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| Authors | 仲田房蔵* |
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| Organization | *北里大学医学部麻酔科 |
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| Journal | 循環制御 |
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| Volume | 5 |
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| Number | 3 |
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| Page | 367-378 |
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| Year/Month | 1984/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「要旨」吸入麻酔薬のhalothane, enfluraneとカルシウム拮抗薬のverapamil, diltiazem, nifedipineの心筋収縮性に及ぼす相互作用を, イヌの右室摘出心筋標本を用いて比較検討した. 麻酔薬により抑制されたVmax(最大短縮速度), Fm(最大発生張力), maximal dF/dt(最大張力発生速度)は, カルシウム拮抗薬の単独投与と同様に同時投与により量依存性の抑制を示した. 同時投与において麻酔薬により抑制された値を対照値とすると, 両投与の抑制の程度はverapamil, diltiazemでは同程度であるが, nifedipineでは他の2者に比して有意な抑制を示した. カルシウム拮抗薬によるVmaxの抑制は, ヒトの最大有効血中濃度の3×10-7Mではverapamil, diltiazemともに9%と弱く, 生体では反射性交感神経緊張により相殺されるため両者の併用は許容し得る. しかしながら, nifedipineでは24%と強く, その直接的な負の変力効果が3x10-7M以上の濃度では麻酔薬により増強されることより, 臨床で使用する場合には慎重な配慮が必要と思われる. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Interactions on myocardial contractile state between inhalation anesthetics and calcium channel blockers in canine isolated heart muscles |
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| Subtitle | |
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| Authors | Fusazo Nakata* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology Kitasato University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 5 |
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| Number | 3 |
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| Page | 367-378 |
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| Year/Month | 1984/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Combined effects of inhalation anesthetics (halothane, enflurane) and calcium channel blockers (verapamil, diltiazem, nifedipine) on myocardial contractile state were compared utilizing canine isolated heart muscle preparations. Dose-dependent decreases in maximal velocity of shortening (Vmax), maximal developed isometric force (Fm), and maximal dF/dt were assessed by either verapamil, diltiazem, or nifedipine alone. Dose-dependent decreases of these variables of muscle mechanics were augmented by additional administration of either halothane or enflurane. Percent reductions of these variables by verapamil or diltiazem were similar both in groups with and without anesthetics, when anesthetics-depressed values were used for the control in groups with halothane or enflurane. However, the negative inotropic effect of nifedipine was potentiated by either halothane or enflurane administration. These data suggest that clinical use of verapamil and diltiazem during halothane or enflurane anesthesia may be acceptable, because the depression of Vmax with the highest therapeutic concentration of these agents were 9%, and because the direct negative inotropism of these calcium channel blockers might be counterbalanced by a reflexsympathetic response in vivo. |
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| Practice | Basic medicine |
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