| Japanese |
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| Title | ハロセン/笑気麻酔下, 急性心筋虚血時におけるCa拮抗薬の心循環系に及ぼす影響-verapamil, diltiazem, nifedipineの比較- |
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| Subtitle | |
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| Authors | 仲田房蔵*, 劒物修** |
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| Organization | *北里大学医学部麻酔科, *東邦大学医学部麻酔科学教室 |
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| Journal | 循環制御 |
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| Volume | 5 |
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| Number | 4 |
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| Page | 455-464 |
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| Year/Month | 1984/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「要旨」29頭のイヌを用いてハロセン麻酔下に急性の心筋虚血を作製後, 3種類のカルシウム拮抗薬を種々の濃度で投与し, verapamil(V), diltiazem(D), nifedipine(N)の心循環系に及ぼす作用を比較検討した. カルシウム拮抗薬の投与量(mg/kg)はV(0.05, 0.1, 0.25), D(0.1, 0.2, 0.5), N(0.01, 0.02, 0.05)であった. Vは量依存性に平均血圧(MAP)を4〜15%, 全末梢血管抵抗(SVR)を19〜23%, 心拍数(HR)を2〜9%それぞれ低下ないし減少させた. 心拍出量(CO), 肺動脈楔入圧(PCWP)は対照値に比して0.05mg/kgでは20%, 9%, 0.1mg/kgでは21%, 10%それぞれ増加ないし上昇した. 0.25mg/kgではPCWPが上昇するが, COは不変, LV dp/dt maxは減少した. DによるMAP, HRの変化はVと同様であったが, 最大投与量でもCO, LV dp/dt maxは増加した. NはMAPを15〜35%, HRを4〜9%それぞれ上昇ないし増加し, CO, LV dp/dt maxもDと同様に増加した. 急性の心筋虚血に対しVの最大投与量を除き, ハロセン麻酔のもとでのカルシウム拮抗薬の使用は左心機能を亢進させる. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Comparative hemodynamic effects of verapamil, diltiazem and nifedipine in acute myocardial ischemia in dogs during halothane/N2O anesthesia |
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| Authors | Fusazo Nakata*, Osamu Kemmotsu** |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Kitasato University School of Medicine, **Department of Anesthesiology, Toho University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 5 |
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| Number | 4 |
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| Page | 455-464 |
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| Year/Month | 1984/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Comparative hemodynamic effects of three calcium entry blockers, verapamil (V), diltiazem (D) and nifedipine (N) in acute myocardial ischemia during halothane/N2O anesthesia were evaluated in 29 mongrel dogs. Serum cathechoamine levels were examined at 30 min after each administration of three calcium entry blockers by the method of high-performance liquid chromatography. Myocardial ischemia was produced by ligation of the left anterior descending coronary artery. Three different i.v. doses (mg/kg) of V (0.05, 0.1, 0.25), D (0.1, 0.2, 0.5) or N (0.01, 0.02, 0.05) were used. Each dose was administered at 30 min intervals. V reduced systemic vascular resistance (SVR) by 19-23%, mean arterial pressure (MAP) by 4-15% and heart rate (HR) by 2-9%, dose-dependently. Percent increases in cardiac output (CO) and pulmonary capillary wegde pressure (PCWP) were 20 and 9 by 0.05mg/kg, and 21 and 10 by 0.01 mg/kg, respectively. CO was unchanged and LV dp/dt max was slightly reduced with increased PCWP by 0.25 mg/kg. |
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| Practice | Basic medicine |
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