| Japanese |
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| Title | 実験的甲状腺機能亢進に由来する高血圧家兎の大動脈圧受容器機能の変化 |
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| Subtitle | |
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| Authors | 友松栄二*, 武井茂樹*, 大場秀一*, 平尾修*, 吉原光恵*, 竹田幸一* |
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| Authors(kana) | |
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| Organization | *独協医科大学循環器内科 |
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| Journal | 循環制御 |
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| Volume | 6 |
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| Number | 1 |
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| Page | 53-57 |
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| Year/Month | 1985/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「要旨」甲状腺末を4週投与して生じた実験的甲状腺機能亢進にもとつく高血圧家兎の大動脈圧受容器神経放電を定性的に調べた. 甲状腺末を4週投与すると有意に血圧上昇, 脈圧増大, 心拍数の増加を生じた. 高血圧家兎では, 正常血圧家兎に比べて, 大動脈圧受容器求心性神経活動は高い血圧レベルで放電を開始した. 甲状腺機能亢進にもとづく2次性高血圧症では, 高圧降圧受容器機能は高い血圧レベルで作動していることが考えられる. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | Aortic baroreceptor resetting of hypertensive rabbits induced by experimental hyperthyroidism |
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| Subtitle | |
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| Authors | Tomomatsu Eiji, Takei Shigeki, Ohba Hideichi, Hirao Schu, Yoshihara Terue, Takeda Kouichi |
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| Authors(kana) | |
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| Organization | Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 6 |
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| Number | 1 |
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| Page | 53-57 |
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| Year/Month | 1985/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Aortic baroreceptor function was studied in hypertensive rabbits induced by experimental hyperthyroidism. Hypertension was produced by four weeks treatment of dessicated thyroid (0.5g/day). In the seven hypertensive rabbits, elevated arterial blood pressure and increased heart rate were observed. Their mean arterial pressure (146.0 ± 2.4mmHg) and heart rate (366.6 ± 10.3baets/min) were higher than the corresponding values in seven control normotensive rabbits. A multifiber preparation of the aortic nerve was used to analyze the baroreceptor firing range. Upward shift of the baroreceptor range of baroreceptor activation was observed in hypertensive rabbits. The average systolic/diastolic pressure threshold for baroreceptor activation in the control rabbits was 64.0 ± 3.7 / 35.0 ± 2.1mmHg, while that of hypertensive rabbits was 11.09 ± 4.4 / 74.0 ± 3.5mmHg. These findings demonstrate that aortic baroreceptor activities in the hypertensive rabbits induced by experimental hyperthyroidism reset to a higher blood pressure. |
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| Practice | Basic medicine |
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| Keywords | Baroreceptor resetting, Hypertension, Hyperthyroidism, Aortic baroreceptors |
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