| Japanese |
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| Title | Ca拮抗剤と心筋保護:nifedipineの効果に関する実験的研究 |
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| Authors | 山本文雄*, 内藤泰顕*, 藤田毅*, 川副浩平*, Braimbridge, M.V.**, Hearse, D.J.** |
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| Organization | *国立循環器病センター心臓外科, **The Rayne Institute, The St. Thomas Hospital |
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| Journal | 循環制御 |
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| Volume | 6 |
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| Number | 1 |
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| Page | 59-67 |
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| Year/Month | 1985/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「要旨」Isolated rat heart preparationを用い, nifedipineの心筋保護作用について検討した, 常温虚血下, nifedipineをSt. Thomas液に添加して検討したところ, 0.075μmoles/lを至適濃度とするbell型のdose respons curveを示したが, 低温虚血下では, 何ら心機能の回復率の増加を認めなかった. 同様の実験モデルを用い, nifedipineが, St. Thomas液とreplace可能か否かについて検討した. その結果常温虚血下では, ある程度の効果を認めるが, 低温虚血下では有効性は認められず, nifedipineとhypothermiaとの保護効果に関する関連性が示唆された. 又, nifedipine単独では, St. Thomas液の保護効果ほど有効でなく, nifedipine単独でSt. Thomas液をreplaceすることは困難であることが判明した. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Calcium Antagonists and cardioplegia : rat heart studies with the St. Thomas' cardioplegic solution |
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| Authors | Fumio Yamamoto*, Yasuaki Naito*, Tsuyoshi Fujita*, Braimbridge M.V**, Hearse D.J** |
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| Authors(kana) | |
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| Organization | *Department of Cardiovascular Surgery, National Cardiovascular Center, **The Rayne Institute, The St. Thomas Hospital |
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| Journal | Circulation Control |
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| Volume | 6 |
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| Number | 1 |
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| Page | 59-67 |
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| Year/Month | 1985/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The ability of nifedipine to enhance myocardial protection was assessed using an isolated rat heart model of cardiopulmonary bypass and ischaemic cardiac arrest. With normothermic ischaemic arrest, nifedipine addition improved the protective properties of the St. Thomas' cardioplegic solution. Optimal protection was observed with 0.075 μmol nifedipine・liter-1, where post-ischaemic recovery of aortic flow was improved from 47.9 ± 5.2% to 76.7 ± 2.9% (p<0.001) and creatine kinase leakage was reduced by approximately 50%. Despite the marked additional protection under normothermic conditions the drug was unable to improve contractile recovery after a period of hypothermic ischaemic arrest (150 min, 20℃). In other studies, the ability of nifedipine to replace the cardioplegic solution was examined. Under normothermic conditions, it showed a good ability to protect against ischaemia, but this protection did not match that afforded by the St. Thomas' cardioplegic solution. Under hypothermic conditions the drug failed to substiute for the cardioplegic solution, suggesting that a common modality between hypothermia and nifedipine induced protection. |
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| Practice | Basic medicine |
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| Keywords | calcium antagonists, nifedipine, cardioplegia, myocardial protection, hypothermia |
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