| Japanese |
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| Title | 高負荷ラット灌流心におけるdiltiazemの心筋保護作用 |
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| Subtitle | |
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| Authors | 樫本温*, 日野原真一**, 熊沢光生*, 田中行夫* |
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| Authors(kana) | |
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| Organization | *山梨医科大学麻酔科学教室, **山梨県立中央病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 6 |
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| Number | 2 |
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| Page | 135-139 |
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| Year/Month | 1985/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「要旨」Ca拮抗薬はCa＋＋イオン流入抑制による心筋収縮力低下, 心拍数の減少, 末梢抵抗の低下による左室負荷の軽減によって心筋酸素消費量を減少させることが, 虚血時に心筋保護作用をもたらす機序のひとつとして考えられている. 我々は心仕事量を一定とした場合に, 高負荷による心筋虚血に対してdiltiazemが保護作用を示すか否かをラットの心肺標本を用い, 灌流血液中に流出するCPKの量で検討した. その結果diltiazem群では有意に心筋細胞からのCPKの流出が抑制された. diltiazemの心筋細胞への直接の保護効果が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | Protective effect of diltiazem on pressure-loaded working heart |
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| Subtitle | |
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| Authors | Satoshi Kashimoto, Shinichi Hinohara, Yukio Tanaka, Teruo Kumazawa |
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| Authors(kana) | |
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| Organization | Department of Anesthesia, Yamanashi Medical College |
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| Journal | Circulation Control |
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| Volume | 6 |
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| Number | 2 |
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| Page | 135-139 |
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| Year/Month | 1985/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | To investigate a protective action of diltiazem on high afterload, we studied effects on cellular damage in a isolated rat heart lung preparation. Diltiazem appeared to diminish irreversible damage as shown by its effect in reducing CPK release. In this isolated rat heart lung preparation, effects on the peripheral circulation can be excluded as a site of action. Hence, this study shows a direct protective effect on the heart with high afterload which is not achieved by decreased heart work. |
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| Practice | Basic medicine |
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| Keywords | Calcium channel inhibitor, Creatinephosphokinase, Diltiazem, Heart lung preparation |
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