| Japanese |
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| Title | 2. 心拍出量に対する後負荷の影響-機械的, 薬物的アプローチ- |
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| Subtitle | 特集-第6回循環制御研究会記録 IV. シンポジウム「心拍出量とAfterloadを考える」 |
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| Authors | 吉沢由利子*, 井上荘三郎*, 清水禮壽**, 粕田晴之**, 赤沢訓**, 根本邦夫** |
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| Organization | *虎の門病院麻酔科, **自治医科大学麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 6 |
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| Number | 3 |
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| Page | 299-303 |
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| Year/Month | 1985/ |
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| Article | 報告 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「要旨」インフルレン麻酔犬を用い後負荷と心拍出量(CO)の関係を検討した. 同時に, 超音波方式により左室拡張終期横径を測定した. 後負荷(動脈圧)は胸部下行大動脈クランプあるいはメトキサミン(0.04mg/kg)のbolus投与により増大させ, 胸部下行大動脈デクランプ, ニカルジピン(0.01mg/kg)あるいはニトログリセリン(0.02mg/kg)のbolus投与により減少させた. 1%インフルレン麻酔下では後負荷増大によりCOは一過性にのみ減少した. 3%インフルレン麻酔下では後負荷増大によりCOは減少したままであった. 後負荷減少によりCOは増加した. CaCl2(5mg/kg)やエピネフリン(0.3μg/kg)では後負荷が増大した場合でも, COは増加した. 以上より, 心臓は浅麻酔下ではスターリングの法則に従って機能するが, 深麻酔下では後負荷の増加により, 容易に不全状態に陥ること, 強心薬は後負荷の変動にかかわりなくCOの増加をもたらすことが明らかにされた. 「目的」機械的あるいは薬物的に左心室の後負荷を変動させ, 後負荷と心拍出量(CO)との関係を中心に検討した. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Effects of Mechanically or Pharmacologically Changed Afterload on Cardiac Output |
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| Authors | Yuriko Yoshizawa, Souzaburo Inoue, Reiju Shimizu*, Haruyuki Kasuda*, Satoshi Akazawa*, Kunio Nemoto* |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Toranomon Hospital, *Department of Anesthesiology, Jichi Medical School |
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| Journal | Circulation Control |
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| Volume | 6 |
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| Number | 3 |
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| Page | 299-303 |
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| Year/Month | 1985/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Effects of afterload on cardiac output were studied in isoflurane anesthetised dogs. The transversus diameter of the left ventricle was measured by ultrasound. Afterload (arterial pressure) was increased by clamping the thoracic descending aorta or the intravenous administration of methoxithamine (0.04 mg・kg-1). Afterload was reduced by declamping the thoracic descending aorta or the intravenous administration of nicardipine (0.01 mg・kg-1) or nitroglycerine (0.02 mg・kg-1). During 1% isoflurane anesthesia, cardiac output was decreased transiently by an increase of afterload. During 3% isoflurane anesthesia, cardiac output remained decreased by an increase of afterload. During 1 or 3% isoflurane, cardiac output was increased by a reduction of afterload. Inotropic agents such as Cacl2 (5 mg・kg-1) or epinephrine (0.3 μg・kg-1) increased cardiac output, even when afterload was increased. Our study showed that during light anesthesia, the heart functioned according to Starlig's law, but during deep anesthesia, an increase of afterload easily developed cardiac failure and inotropic agents increased cardiac output, regardless of any changes in afterload. |
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| Practice | Basic medicine |
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| Keywords | afterload, cardiac output, Starling's law, inotropic agent, isoflurane anesthesia |
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