| Japanese |
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| Title | AC bypass手術におけるカルシウム拮抗薬の血行動態に及ぼす影響-ニトログリセリン単独投与とディルチアゼム併用投与との比較- |
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| Authors | 辻本三郎*, 瀬尾憲正*, 川崎道朗*, 南ちひろ*, 白永潤*, 山崎和夫*, 加藤浩子*, 宮本覚**, 庄村東洋** |
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| Authors(kana) | |
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| Organization | *神戸市立中央市民病院麻酔科・集中治療部, **神戸市立中央市民病院胸部心臓血管外科 |
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| Journal | 循環制御 |
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| Volume | 6 |
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| Number | 3 |
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| Page | 331-338 |
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| Year/Month | 1985/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「はじめに」虚血性心疾患に対する外科的治療としての大動脈-冠動脈バイパス手術(以下AC bypass手術と略す)は, 我が国でも近年増加しており, 心臓手術の中でもポピュラーな手術となってきている. AC bypass手術の術中術後管理上, 心筋虚血の予防は最も重要な問題であり, 心筋酸素需要供給のバランスをいかにして適正に保つかが最大の要点である. 最近では, AC bypass手術に際して多くの施設で, 心筋虚血の予防の目的にニトログリセリン(以下TNGと略す)やカルシウム拮抗薬(以下Ca拮抗薬と略す)が単独または併用して投与されるようになったが, 術後早期の血行動態にこれら2剤の及ぼす影響を詳細に比較検討した報告は少ない. 今回, 我々はAC bypass手術術後早期の血行動態を中心にTNG単独投与群とCa拮抗薬であるDiltiazemの併用投与群とを比較検討し, TNGとDiltiazemの併用投与により術後の血行動態は良好に維持でき, 心筋虚血の予防に有用であると思われたので報告する. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Early Postoperative Hemobynamics after Coronary Artery Bypass Surgery : Effects of Combined Continuous Infusion of Nitroglycerin and Diltiazem |
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| Authors | Saburo Tsujimoto*, Norimasa Seo*, Michiro Kawasaki*, Chihiro Minami*, Eijun Haku*, Kazuo Yamazaki*, Hiroko Kato*, Satoru Miyamoto**, Touyou Shoumura** |
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| Organization | *Department of Anesthesia and ICU, Kobe Central Municipal Hospital, **Department of Thoracic Cardiovascular Surgery, Kobe Central Municipal Hospital |
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| Journal | Circulation Control |
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| Volume | 6 |
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| Number | 3 |
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| Page | 331-338 |
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| Year/Month | 1985/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | TNG and Diltiazem were infused continuously during and in early postoperative period of CABG operations. The early postoperative hemodynamics were compared to that of administration of TNG alone. 61 patients were grouped into: I = TNG 0.2-0.5 μg/kg/min (n=7) ; II=TNG 0.2-0.5 μg/kg/min + Diltiazem 0.5 μg/kg/min (n=10) ; III=TNG 0.2-0.5 μg/kg/min + Diltiazem 1.5 μg/kg/min (n=44). The results obtained were as follows. (1) Compared to group I, bradycardia and mild hypotensive tendency were observed in group II and III, however, less peripheral vascular resistance and increase in cardiac output were observed with the latter groups. (2) RPP was increased in group I but decreased in both group II and III. (3) The above results were more prominent in group III than in group II. Therefore, we concluded that combined administration of TNG and Diltiazem would improve the postoperative hemodynamics and reduce myocardial work. |
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| Practice | Basic medicine |
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| Keywords | CABG operation, Nitroglycerine (TNG), Diltiazem Hemodynamics |
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