| Japanese |
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| Title | 術中, 麻酔覚醒期および抜管後の血圧上昇に対するジルチアゼム(CRD-401)持続点滴静注法による降圧効果の検討 |
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| Subtitle | |
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| Authors | 外須美夫*, 佐々木剛**, 相島和子**, 高橋成輔*, 吉武潤一** |
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| Organization | *九州大学医学部附属病院手術部, **九州大学医学部麻酔科 |
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| Journal | 循環制御 |
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| Volume | 6 |
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| Number | 3 |
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| Page | 339-344 |
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| Year/Month | 1985/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「要旨」静脈内投与が可能なCa拮抗剤, ジルチアゼム(CRD-401)を用いて, 術中, 麻酔覚醒期および抜管後の血圧上昇に対する降圧効果の検討を行なった. 持続点滴法にてジルチアゼムを投与した結果, 覚醒期高血圧群では20〜30μg/kg・minの投与量にて収縮期血圧の約20%の降圧が得られた. 術中高血圧群では, より大量を要し, 降圧効果が前2群より得られにくかった. 全体として降圧効果の判定結果は著効47%, 有効43%, 無効10%であった. 副作用として30例中2例に房室解離が認められた. 以上より静脈内ジルチアゼム投与法は周術期の血圧上昇に対して有用であると思われた. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Antihypertensive effect of continuous infusion of diltiazem (CRD-401) on the elevation of blood pressure observed during perioperative stages |
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| Subtitle | |
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| Authors | Sumio Hoka*, Takeshi Sasaki**, Kazuko Aishima*, Shosuke Takahashi*, Junichi Yoshitake** |
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| Authors(kana) | |
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| Organization | **Department of Anesthesiology, Faculty of Medicine, Kyushu University, *Operating Rooms, Kyushu University |
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| Journal | Circulation Control |
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| Volume | 6 |
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| Number | 3 |
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| Page | 339-344 |
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| Year/Month | 1985/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | This study was designed to examine the antihypertensive effect of intravenous diltiazem (CRD-401) on the elevation of blood pressure observed during three perioperative stages : 1) during surgical operation under anesthesia (group I, n=7), 2) on awaking from general anesthesia (group II, n=14), 3) after extubation of the endotracheal tube (group III, n=9). Continuous infusion of diltiazem 20〜30 μg/kg/min significantly decreased systolic blood pressure by approximately 20% both in group II and group III. In group I, higher doses of diltiazem were needed to obtain an effective reduction of blood pressure. Two out of 30 patients developed A-V dissociation, which terminated spontaneously after reducing the rate of infusion. These results suggest that an intravenous infusion of diltiazem is effective in treating high blood pressure in perioperative patients. |
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| Practice | Basic medicine |
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