| Japanese |
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| Title | 吸入麻酔薬とnicardipineの心筋収縮性に及ぼす影響 |
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| Authors | 仲田房蔵*, 劒物修**, 田中亮* |
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| Organization | *北里大学医学部麻酔科, **東邦大学医学部麻酔科 |
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| Journal | 循環制御 |
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| Volume | 6 |
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| Number | 3 |
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| Page | 345-352 |
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| Year/Month | 1985/ |
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| Article | 原著 |
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| Publisher | 日本循環制御研究会 |
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| Abstract | 「要旨」吸入麻酔薬のhalothane. enfluraneとカルシウム拮抗薬のnicardipineの心筋収縮性に及ぼす相互作用を, イヌの右室摘出心筋標本を用いて比較検討した. Nicardipineの単独投与及びhalothane, enfluraneにより抑制された状態での同時投与は, Vmax(最大短縮速度), Fm(最大発生張力), maximal dF/dt(最大張力発生速度)を量依存性に抑制した. VmaxのDC50(50% Depression of Contractility)は単独投与1.0×10-4, halothane同時投与3.0×10-6M, enflurane同時投与7.0×10-6Mであり, 他のカルシウム拮抗薬のverapamil, diltiazem, nifedipineに比べ高かった. 同時投与において麻酔薬により抑制された値を対照値とすると, 両投与の抑制は同程度であった. NicardipineのVmaxの抑制はヒトの最大有効血中濃度の3×10-7Mでは12%と弱く, 生体では反射性交感神経緊張のより相殺されるため両者の併用は許容しうる. むしろ頻脈や心筋酸素消費量の増加に対する慎重な配慮が必要と思われる. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Combined effects of inhalation anesthetics and nicardipine on myocardial contractile state in canine isolated heart muscle |
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| Authors | Fusazo Nakata*, Osamu Kemmotsu**, Ryo Tanaka* |
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| Organization | *Depertment of Anesthesiology, Kitasato University School of Medicine, **Depertment of Anesthesiology, Toho University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 6 |
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| Number | 3 |
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| Page | 345-352 |
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| Year/Month | 1985/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Interactions on myocardial contractile state between inhalation anesthetics (halothane, enflurane) and calcium channel blocker (nicardipine) were compared utilizing canine isolated heart muscle preparations. Nicardipine alone and additional adimnistration of either halothane or enflurane decreased in maximal velocity of shortening (Vmax), maximal developed isometric force (Fm), maximal dF/dt dose-dependently, DC50 (50% Depression of Contractility) by nicardipine were higher than verapamil, diltiazem or nifedipine with and without anesthetics as previously reported. Percent reductions of these variables were similar with nicardipine alone and with anesthetics, when anesthetics-depressed values were used for the control. From these data, it is concluded that clinical use of nicardipine during halothane or enflurane anesthesia may be acceptable, because the depression of Vmax with the highest therapeutic concentration of nicardipine was 12%, and because the direct negative inotropism of nicardipine might be counteracted by a reflex sympathetic response in vivo. However, severe reflex tachycardia should be avoided in order to prevent increase of myocardial oxygen demand. |
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| Practice | Basic medicine |
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