| Japanese |
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| Title | A-Cバイパス手術患者における硝酸イソソルビドの経皮的吸収に関する研究 |
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| Subtitle | 原著 |
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| Authors | 福井明, 酒井資之, 福富悌, 高折益彦 |
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| Organization | 川崎医科大学麻酔科学教室 |
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| Journal | 循環制御 |
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| Volume | 7 |
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| Number | 2 |
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| Page | 731-735 |
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| Year/Month | 1986/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 経皮吸収型ISDN製剤80mgを低体温・体外循環使用のA-Cバイパス手術症例に使用し, 本剤の経皮的吸収についての検討を行った. すなわち, テープ貼付前, 貼付後3, 8, 16, 24時間の動脈血中ISDN濃度と直腸温, 貼付部皮膚温を測定した. この結果, 対照に比して血中ISDN濃度は貼付後3,16時間では有意に低値, 貼付後8時間では低値傾向であった. しかし血中ISDN値が最低値を示した貼付後8時間でも3.52±2.06ng／mlを示し, 本剤の抗狭心症作用を有するとされている血中濃度以上となっていた. また貼付部位による血中濃度におよぼす影響を一般手術症例について検討したがその影響は認められなかった. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | transcntaneonr absorption, isosorbide dinitrate, aorto-coronary bypass |
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| English |
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| Title | Transcutaneous absorption of isosorbide dinitrate in cardiac patients undergone aorto-coronary bypass grafting surgery |
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| Authors | Akira Fukui, Takayuki Sakai, Osamu Fukutomi, Masuhiko Takaori |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Kawasaki Medical School |
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| Journal | Circulation Control |
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| Volume | 7 |
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| Number | 2 |
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| Page | 731-735 |
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| Year/Month | 1986/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Transcutaneous absorption of isosorbide dinitrate（ISDN） from ISDN tape（FRANDOL(R)） was studied in eight patients undergone aortocoronary bypass grafting operation during hypothermic, extracorporeal circulation and the subsequent period. ISDN tape（contained 80 mg of ISDN） was put on their back before the induction of anesthesia and serum ISDN concentration, blood pressure, heart rate, temperature of the skin the tape put on and the rectum were measured serially for 24 hours. The serum ISDN concentration at 3 hours after the treatment was approximately 2／5 of those in eight patients, as the control, abdominal surgery performed. However the concentration of 3.52±2.06 ng／ml at the 3 hours remained within the effectively protective range for anti-anginal attack. No marked differences between the groups were noted subsequently. Application of the tape on the frontal chest in other 8 patients with abdominal surgery showed the most identical changes in their serum concentration of ISDN as those in the former control group. |
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| Practice | Basic medicine |
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| Keywords | transcntaneonr absorption, isosorbide dinitrate, aorto-coronary bypass |
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