| Japanese |
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| Title | NLA麻酔下手術患者に生じた血圧上昇のニカルジピンによる治療 |
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| Subtitle | 原著 |
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| Authors | 松本信夫*, 大隅昭幸*, 高折益彦*, 新谷潤二** |
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| Authors(kana) | |
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| Organization | *川崎医科大学麻酔科, **明和病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 7 |
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| Number | 2 |
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| Page | 737-744 |
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| Year/Month | 1986/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | NLA変法麻酔下にある手術患者に発生した血圧上昇をニカルジピン（16.9±9.1μg／kg）の静脈内投与によって治療した. 収縮期血圧は投与前の87±12％に低下し, ほぼ30分間は投与前値に達することはなかった. 投与後の最低収縮期血圧は5〜10分に全体の63.7％にみとめられた. 血圧低下の程度はニカルジピン投与量にやや比例する傾向を示すものの, 投与前血圧, 年齢, 輸液量に影響を受けていなかった. 拡張期血圧も同様の傾向を示すものの投与量増加とともに投与後5分時値は投与前値に関係なく84±16mmHgに集束することがみとめられた. この間心拍数に有意な変化はみとめられず, 第3者による回顧的, かつ客観的判定においても心拍数増加は180例中13例（7.2％）であった. 同様の判定にもとずく本薬の治療効果は87.8％に有効であり, 20μg／kg以上の投与において無効例が減少する傾向（P=0.13）が認められた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | nicardipine hypertension anesthetic management dose response |
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| English |
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| Title | Efficacy of intravenous administration of nicardipine hydrochloride for the treatment of hypertention during surgical operation |
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| Subtitle | |
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| Authors | Matsumoto, Nobuo*, Ohsumi, Akiyuki*, Takaori, Masuhiko*, Shintani, Junji** |
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| Authors(kana) | |
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| Organization | *Kawasaki Medical School Department of Anesthesiology, **Meiwa General Hospital Division of Anesthesia |
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| Journal | Circulation Control |
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| Volume | 7 |
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| Number | 2 |
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| Page | 737-744 |
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| Year/Month | 1986/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Nicardipine hydrochloride（16.9±9.1μg／kg） was administered 180 times intravenously for treatment of hypertension in 154 patients who were anesthetized with nitrous-oxide and oxygen associated with pentazocine and diazepam and in whom major surgery was being carried out. The treatment decreased their systolic arterial pressure to 87±12％ of control and maintained in the mostly identical level for 30 minutes. The minimal systolic pressure was noted in interval of 5-10 minutes after the administration in 109 cases, 64％ of 171（9 cases were excluded, whose systolic pressure was either unchanged or increased after the treatment from the whole group）. The similar changes were observed in their diastolic pressure. These changes in arterial pressure were not effected either by the dose of nicardipine given, patient's age or fluid volume given prior to the administration. It was noted, however, that diastolic pressure at 5 minutes after the administration with relatively higher doses（over 20 μg／kg） seemed to be converged to 84±16 mmHg not related to their pretreated levels. |
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| Practice | Basic medicine |
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| Keywords | nicardipine hypertension anesthetic management dose response |
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