| Japanese |
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| Title | 心臓血管術後患者の難治性頻脈に対する静注用ジルチアゼムの効果 |
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| Authors | 謝慶一*, 公文啓二*, 平田隆彦*, 田中一彦*, 鬼頭義次**, 小原邦義**, 藤田毅** |
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| Authors(kana) | |
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| Organization | *国立循環器病センターICU, **国立循環器センター, 心臓血管外科 |
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| Journal | 循環制御 |
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| Volume | 8 |
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| Number | 1 |
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| Page | 99-103 |
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| Year/Month | 1987/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 心臓血管術後患者において心拍数の安定化は有効な心拍出量を得ることからも非常に重要な因子のひとつである. しかし, 各種薬剤に抵抗する頻脈発作に遭遇しその治療に難渋する場合がある. 今回我々は心臓血管術後患者12例に発生し強心配糖体やディソピラマイドに抵抗を示した難治性頻脈に対してslow channel blockerのひとつである塩酸ジルチアゼムを心筋収縮力抑制作用が有意に発現しない様な低濃度（0.8〜2.0μg／kg・min）にて持続静脈内投与を行い, 投与前値と投与開始約1時間後の心拍数を比較検討することにより良好な結果を得たので若干の考察を加えてここに報告する. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | The efficacy of intravenous diltiazem hydrochloride （CRD 401） for the treatment of refractory tachyarrhythmia following cardiovascular surgery. |
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| Subtitle | |
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| Authors | Keiichi Sha*, Keiji Kumon*, Takahiko Hirata*, Kaznhiko Tanaka*, Yoshitugu Kitou**, Kuniyoshi Ohara**, Tsuyoshi Fujita** |
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| Authors(kana) | |
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| Organization | *Department of Intensive Care Unit, National Cardiovascular Center, **Department of Cardiovascular Surgery, National Cardiovascular Center |
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| Journal | Circulation Control |
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| Volume | 8 |
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| Number | 1 |
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| Page | 99-103 |
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| Year/Month | 1987/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Diltiazem hydrochloride, a slow channel blocker, is known to have various effects on cardiovascular system such as reduction of systemic vascular resistance, diltiazem of coronary artery, suppression of myocardial contractility and decrease of heart rate. This study was undertaken to evaluate the efficacy of intravenous administration of diltiazem hydrochloride （CRD 401） on refractory tachyarrythmias following cardiovascularsurgery （CVS）. CRD 401 was administrated continiously by intravenous infusion at the rate of 0.8 to 2.0 μg／kg・min on 12 patients who were suffering from an intractable tachyarrhythmia after CVS. The type of tachyarrhythmias were atrial fibrillation or fiutter in patients （group A） and supraventricular tachyarrythmia in 5 patients （group S）. These tachyarrythmia were not controlled by other antiarrhythmic drugs. A marked reduction of heart rate was obtained in all patients within an hour of the administration of CRD 401 without showing any compromise on cardiac performance. |
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| Practice | Basic medicine |
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