Japanese
Titleイソフルレン麻酔下におけるジルチアゼムbolus静注の心循環系への作用
Subtitle
Authors岩月尚文, 今村勉, 皆頼敦, 古賀義久
Authors(kana)
Organization東北大学医学部麻酔学教室
Journal循環制御
Volume8
Number1
Page105-110
Year/Month1987/
Article原著
Publisher日本循環制御医学会
AbstractDiltiazem(DL)bolus投与による心循環系の反応を, 犬を用いIsoflurane(Iso)麻酔下とウレタン・クロラロース麻酔下(対照群)で比較し, 相互作用を検討した. 心循環系へのDLの作用態度は, LV dp/dtと心拍数以外, Iso群と対照群でその程度に差がなく, Isoの存在により影響をうけないと考えられ, さらにDLとIsoの心循環系に対する抑制作用は相加的であると云える. LV dp/dtは高濃度DLによりIso下でより抑制され, 心拍数は抑制程度は対照群と同じであるが, 抑制持続時間がIso下でより長くなった. これらのDLの反応態度は, Halothane下におけるものとほぼ同じであった.
Practice基礎医学・関連科学
Keywords
English
TitleInteraction of isoflurane and diltiazem upon cardiovascular function in the dog
Subtitle
AuthorsNaofumi Iwatsuki, Tsutomu Imamura, Atsushi Kaise, Yoshihisa Koga
Authors(kana)
OrganizationDepartment of Anesthesiology, Tohoku University School of Medicine
JournalCirculation Control
Volume8
Number1
Page105-110
Year/Month1987/
ArticleOriginal article
PublisherJapan Society of Circulation Control
AbstractEffects of bolus injection of diltiazem(DL) upon cardiovascular functions were compared between under 1−MAC of isoflurane (Iso group) and urethane−chloralose anesthesia (C group). Blood pressure, systemic vascular resistance, left ventricular pressure transiently (5 min) decreased, cardiac output (CO) and left atrial pressure transiently increased, and left ventricular (LV) dp/dt, pulmonary arterial pressure and resistance (PVR) were not altered in C group. The percent changes in these indices of C group did not differ to those of Iso group, except in CO, LV dp/dt and PVR. The increase in CO was smaller, and LV dp/dt and PVR depressed only with the higher dose of DL in Iso group. DL decreased heart rate (HR) in the same degree (in %) in both group, but the duration of this decrease was longer in Iso group. Thus, Iso does not modified cardiovascular responses to DL, and both drugs interact additively to each other, except on HR and LV dp/dt.
PracticeBasic medicine
KeywordsCardiovascular function, Isoflurane, Diltiazem, Interactions.

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