| Japanese |
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| Title | ドブタミンとニトログリセリンの併用投与が, 虚血心におよぼす影響（血行動態についての検討） |
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| Subtitle | |
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| Authors | 長浜弘道 |
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| Authors(kana) | |
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| Organization | 聖マリアンナ医科大学麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 8 |
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| Number | 3 |
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| Page | 393-399 |
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| Year/Month | 1987/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 冠動脈結紮による急性心筋虚血を犬に作成し, dobutamine（DOB） 5μg／kg／min, nitroglycerin（TNG）1, 3μg／kg／min併用投与時の血行動態について検討した. DOB, TNGの単独投与では虚血群に比べるとポンプ機能等の指標の改善は軽度であったが, 対照群に比べると低値であった. 併用投与によりポンプ機能, 圧負荷および心筋酸素平衡を示す指標の改善を認めた. さらに虚血群に比べて健常部, 虚血部とも著明な局所心筋血流量の増加を認めたことから, 急性心筋梗塞によるポンプ不全に対しDOB・TNG併用投与は血行動態を改善し有効との示唆を得た. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | Hemodynamic Effects of Dobutamine and Trinitroglycerin in Ischemic Heart |
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| Subtitle | |
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| Authors | Hiromichi Nagahama |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, St. Marianna University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 8 |
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| Number | 3 |
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| Page | 393-399 |
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| Year/Month | 1987/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Recently, it has reported that combined administration of vasodilator with β-adrenergic agonist was useful in cardiogenic shock of acute myocardial infarction and severe heart failure. Trinitroglycerin （TNG） has been known as the drug for angina pectoris and reduces preload mainly. Therefore, the hemodynamic effect of TNG combined with dobutamine （DOB） were studied in experimental ischemic heart of dogs. After stable anesthesia, control hemodynamic parameters were measured. Acute myocardial ischemia was produced by ligation of the left anterior descending artery. Then hemodynamic changes produced by the administration of DOB combined with TNG were compared with those by DOB alone and TNG alone. The combination of DOB with TNG caused increments of cardiac index, stroke volume index and regional myocardial blood flow in ischemic area mainly and caused decrement of total peripheral resistance more significant than DOB alone or TNG alone. It was sugested that the combination of DOB with TNG improved cardiac function in heart failure and had beneficial effects in ischmic heart. |
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| Practice | Basic medicine |
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| Keywords | Dobutamine, Trinitroglycerin, Myocardial ischemia |
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