| Japanese |
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| Title | 気管内心機図の流量変化と心機能との関連について |
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| Subtitle | |
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| Authors | 津崎晃一 |
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| Authors(kana) | |
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| Organization | 慶應義塾大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 1 |
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| Page | 75-82 |
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| Year/Month | 1988/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 心拍動に伴うわずかな気管内の気体振動を無呼吸下に呼吸流量計で流量変化としてとらえ, 気管内心機図（ITCG−F）として心機能の評価を行なった. 臨床例でイソフルレンによる心機能への影響を検討すると, ITCG−Fと心エコー法の両者によりそれぞれ心抑制作用を認め, 特に変化率として評価を行なった際のITCG−Fでは, より鋭敏に心抑制作用を示した. また, 両者間で対応すると考えられる各心機能パラメータにおいても良好な相関関係が得られた. さらに, エンフルレン, ハロセン, イソフルレンの各吸入麻酔薬による影響をITCG−Fにより検討すると, それぞれ用量依存性の心抑制作用を示し, 同一MACの比較では, 抑制作用の強い順にエンフルレン, ハロセン, イソフルレンであった. 一方, 動物実験では, ITCG−Fにおける陽性波（BC成分）に及ぼす肺動脈拍動性の影響が認められ, 発生機序の一部に理解が与えられた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | Evaluation of cardiac function using intratracheal air flow changes （Intratracheal pneumocardiogram, ITCG−F） |
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| Subtitle | |
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| Authors | Koichi Tsuzaki |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, School of Medicine Keio University |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 1 |
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| Page | 75-82 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The oscillatory air flow changes in trachea, synchronized with heart beat, are easily obtained by specifically designed pneumotachograph attached to the endotracheal tube during apnea. It has been considered through the analysis of these air flow changes（intratracheal pneumocardiogram, ITCG−F）that there is close relationship between these flow and cardiac function. In animal experiment, negative component（AB） in ITCG recognized with cardiac contraction and its first derivative （max dF／dt）have been reported to be in good correlation with stroke volume and max dP／dt of left ventricle, respectively. Positive component （BC） has been speculated to reflect the involvement of pulmonary circulatipn. Present studies are intended to show the clinical validity of ITCG−F as cardiac function monitor during inhalational anesthesia. Results are as follows. 1）The percent change of AB and max dF／dt demonstrates the decrease of cardiac contractile function under isoflurane anesthesia as sensitively as echocardiography does. 2）ITCG−F shows the decreased cardiac function by inhalational anesthetics （isoflurane, halothane and enflurane）in a dose−dependent manner, and also shows the differences of cardiac depressive action among these anesthetics. 3）Dog experiments using right−sided heart bypass show the pulsatile pressure of pulmonary artery strongly contributes the formation of BC component. |
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| Practice | Basic medicine |
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| Keywords | intratracheal pneumocardiogram, echocardiography, inhalation anesthetics, cardiac function, pulmonary circulation |
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