Japanese
Title臨床的に用いられる前負荷指数の提案
Subtitle
Authors大隅昭幸
Authors(kana)
Organization川崎医科大学麻酔科学教室
Journal循環制御
Volume9
Number1
Page93-101
Year/Month1988/
Article原著
Publisher日本循環制御医学会
Abstractすでに我々が提唱した“前負荷指数（PI）”―すなわち, 熱希釈法を用いて測定した右心房, 右心室容量―と心機能諸因子, 特に心容量に関係する諸因子, 及び心拍出量との相関性をハロセン麻酔下, 人為的に呼吸管理を受けた雑種成犬において動物実験下に検討を加えた. このPIと従来前負荷指数として用いられてきたmRAP（r＝0.43, 0.01＜P＜0.05）及びLVEDP（r＝0.61, p＜0.01）との間に正の相関性を認めた. またQとの間には有意な正の相関（r＝0.59, p＜0.01）を認めた. PIとCBVとの間にはr＝0.43（0.01＜p＜0.05）とやや相関性に乏しい事実が認められた. これは肺血管床が非常に大きなcomplianceを有し, これにより, CBVの変化が直接PIに反映され難いことを示していると思われた. MCPは血液量増加（D群）があるにもかかわらず, わずかな上昇（17mmHg）を示すにすぎなかった. MCPとPIとの間に相関性（r＝0.32）は認められなかった.
Practice基礎医学・関連科学
Keywords
English
TitleAssessment of direct preload index
Subtitle
AuthorsAkiyuki Ohsumi
Authors(kana)
OrganizationDepartment of Anesthesiology Kawasaki Medical School
JournalCirculation Control
Volume9
Number1
Page93-101
Year/Month1988/
ArticleOriginal article
PublisherJapan Society of Circulation Control
AbstractSeveral parameters had been used as a preload to the heart were compared with so called “preload index”, which had been proposed as a precise parameter determining the blood loading to the heart, previously. Namely changes in the cardiac index, right atrial and ventricular pressure, central blood volume and mean circulatory pressure were compared with changes in the preload index, which was expressed by the mean blood volume existing in the right atrium and ventricle and measured by thermodilution method. These circulatory parameters were measured in anesthetized dogs under normovolemia, hypovolemia induced by withdrawal of the circulating blood and hypervolemia induced by infusion of dextran−70 solution. The preload index increased considerably responding to the acute hypervolemia and decreased markedly to the acute hypovolemia. The changes in the preload index correlated with correspondent changes in cardiac index（r＝0.59） and also with changes in the right atrial pressure （r＝0.43）.
PracticeBasic medicine
Keywords

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