| Japanese |
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| Title | セボフルレンの虚血心局所心筋血流量におよぼす影響 |
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| Authors | 郷律子*, 北畑洋*, 神山有史**, 木村英之**, 荒瀬友子***, 斎藤隆雄** |
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| Authors(kana) | |
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| Organization | *徳島大学医学部附属病院手術部, **徳島大学医学部麻酔学教室, ***徳島大学医学部附属病院救急部 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 2 |
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| Page | 189-194 |
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| Year/Month | 1988/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 冠狭窄犬において, セボフルレン（以下Sev）を投与した際の局所心筋血流量を水素クリアランス法を用いて測定し, 虚血心におよぼすSevの影響を検討した. 局所心筋血流量は, 虚血域, 正常域ともに濃度依存性に低下した. I／O比は虚血域では不変であったが正常域は上昇した. この結果よりSevは少なくとも虚血域の層別血流分配を悪化させることはないと思われた. 虚血域／正常域血流量比は低下したが, この結果がSevによるstealを示唆するものか否かは, 他剤との比較検討を要する. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | The Effect of Sevoflurane on Regional Myocardial Blood Flow in Ischemic Heart |
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| Authors | Ritsuko Goh, Hiroshi Kitahata, Arifumi Kohyama, Hideyuki Kimura, Tomoko Arase, Takao Saito |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, The University of Tokushima School of Medicine |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 2 |
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| Page | 189-194 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | In order to study the effects of sevoflurane （Sev） on coronary hemodynamics, we investigated the changes in regional myocardial blood flow （rMBF） in dogs with acute coronary arterial stenosis. Hydrogen clearance method was applied for measurement of rMBF. Eight dogs were anesthetized with intravenous thiamylal and maintained with 1.2％ Sev under mechanical ventilation. A probe of the electromagnetic flowmeter and a constrictor were mounted on the LAD. Wiretype Pt−H2 electrodes were sewed in the inner and outer layers of the region supplied by the LAD and the LCX. After baseline measurement of rMBF and hemodynamics the LAD was constricted until the blood flow fell to 50％ of the baseline. At 1.2％, 2.4％, 3.6％ Sev each, rMBF and hemodynamics were measured. As inspired concentration of Sev increased, heart rate, cardiac ourput, mean arterial pressure and LV dp／dt max were decreased. CVP increased significantly. LVEDP and TPR unchanged. |
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| Practice | Basic medicine |
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| Keywords | sevoflurane, myocardial blood flow, hydrogen clearance method |
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