| Japanese |
|---|
| Title | 22Naと125I Iothalamateの同時測定による間質液の水分移行過程 |
|---|
| Subtitle | |
|---|
| Authors | 田中義文, 橋本悟, 重見研司, 夏山卓, 宮崎正夫 |
|---|
| Authors(kana) | |
|---|
| Organization | 京都府立医科大学麻酔学教室 |
|---|
| Journal | 循環制御 |
|---|
| Volume | 9 |
|---|
| Number | 2 |
|---|
| Page | 195-200 |
|---|
| Year/Month | 1988/ |
|---|
| Article | 原著 |
|---|
| Publisher | 日本循環制御医学会 |
|---|
| Abstract | 22Naと125I Iothalamateの血中濃度減衰曲線より血液間質間の拡散過程を解析した. また乳酸加リンゲル液の循環血の漏出過程を検出し, 生体全体での毛細血管床の水分ろ過係数を求めた. その結果, 間質は均一の分画ではなく, 血漿52ml／kg, 血管周囲自由層63.4ml／kg, とゲル層84.6ml／kgにより構成される3分画モデルが最も良い回帰を示した. また, 水溶性物質の拡散速度は水分ろ過速度の17倍であり, 分時血漿拍出量の25％が水溶性物質の拡散に寄与していることが明らかになった. 本論文で示されている物質輸送の各パラメーターが各種薬剤の血中濃度を解析するうえでの基礎資料になれば幸いである. |
|---|
| Practice | 基礎医学・関連科学 |
|---|
| Keywords | |
|---|
| English |
|---|
| Title | Analysis of Sodium and Iothalamate Diffusion Kinetics Between Vascular Space and Interstitial Fluid Space |
|---|
| Subtitle | |
|---|
| Authors | Y. Tanaka, S. Hashimoto, K. Shigemi, T. Natsuyama, M. Miyazaki |
|---|
| Authors(kana) | |
|---|
| Organization | Department of anesthesiology, Kyoto Prefectural University of Medicine |
|---|
| Journal | Circulation Control |
|---|
| Volume | 9 |
|---|
| Number | 2 |
|---|
| Page | 195-200 |
|---|
| Year/Month | 1988/ |
|---|
| Article | Original article |
|---|
| Publisher | Japan Society of Circulation Control |
|---|
| Abstract | The transvascular diffusion kinetics of lipidinsoluble substances and the fluid exchange in whole body was analyzed from the measurement of 22Na and 125I Iothalamate decay curves and blood volume change consequent to the infusion of Lactate Ringer’s solution. Decay curves of i. v. injected Iothalamate and Na were almost similar in spite of the difference of their molecular size, and their decay curves were in good agreement with three compartment model. Calculated plasma volume, perivascular interstitial free fluid space and interstitial gel space were 52.0, 84.6 and 163ml／kg respectively. Diffusion constant was 16.3ml／kg／min between plasma and free fluid space, and 4.05ml／kg／min between free fluid and gel spaces. The blood volume change was also in good agreement with three compartment model, and compliance of vascular, free fluid and gel spaces were 2.0ml／mmHg／kg, 2.6ml／mmHg and 3.4ml／mmHg respectively. |
|---|
| Practice | Basic medicine |
|---|
| Keywords | |
|---|