| Japanese |
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| Title | ニトログリセリンの静脈コンプライアンス, 血液分布に及ぼす影響について |
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| Subtitle | |
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| Authors | 橋本悟*, 夏山卓*, 重見研司*, 智原栄一*, 木下隆*, 田中義文*, 宮崎正夫*, 森本武利** |
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| Authors(kana) | |
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| Organization | *京都府立医科大学麻酔学教室, **京都府立医科大学生理学教室 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 2 |
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| Page | 209-214 |
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| Year/Month | 1988/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | ハロセン麻酔下の脾摘雑種成犬に対してニトログリセリン（以下GTN）の静脈内投与を行いその心血管系への影響とくに静脈コンプライアンスおよび血液分布に及ぼす影響について調べた. GTN 4μg／kg／minの持続投与により平均動脈圧, 心拍出量, 中心静脈圧および中心循環血液量の有意な減少を認め, 総循環血液量は若干増加した. 一方, 乳酸リンゲル液負荷による総循環血液量と中心静脈圧変化から算出した静脈コンプライアンスはGTN投与で低下傾向を示した. 以上よりGTN投与により1）血液分布は体循環末梢にシフトすること, 2）血液の静脈内貯留がおこるがそれは静脈コンプライアンスの増大ではなくunstressed blood volumeの増加であることが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | THE EFFECTS OF NITROGLYCERIN ON VENOUS COMPLIANCE AND BLOOD VOLUME DISTRIBUTION IN DOGS |
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| Subtitle | |
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| Authors | S. Hashimoto, T. Natsuyama, K. Shigemi, E. Chihara, T. Kinoshita, Y. Tanaka, M. Miyazaki, T. Morimoto |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology and Physiology, Kyoto Prefectural University of Medicine |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 2 |
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| Page | 209-214 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 12 Splenectomized dogs were used for the study. Arterial and central venous pressure were monitored continuously. Cardiac output and central circulating blood volume were measured by dye dilution method. Total blood volume was continuously measured with 51−Crlabeled red blood cells injection using extracorporeal shunt. Each variable was monitored during and after the infusion of 10 ml／kg of lactated Ringer’s solution, with and without GTN. Venous compliance was obtained from the change of blood volume and central venous pressure during the infusion. Result： The administration of GTN does not alter the total blood volume and cardiac output. While central venous pressure and central circulating blood volume decreased significantly. The change of blood volume during the infusion showed that more amount of fluid remained in vascular system in GTN group. And the venous compliance decreased slightly. |
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| Practice | Basic medicine |
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| Keywords | nitroglycerin, venous compliance, blood volume |
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