| Japanese |
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| Title | 末梢血管拡張薬cinepazideの冠循環, 腎循環に及ぼす影響 |
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| Authors | 原田知和, 曽根健之, 塚原郁夫, 上松治孝, 山本道雄 |
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| Organization | 岐阜大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 2 |
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| Page | 215-219 |
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| Year/Month | 1988/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 雑種成犬8頭に, 脳循環障害治療薬cinepazideを10mg／kg／10min, で投与し, その後60分間において冠循環, 腎循環に及ぼす影響を検討した. 平均動脈圧, 心拍数は不変であったが, 心拍出量は増大傾向を, 全末梢血管抵抗は減少傾向を示した. 冠血流量は対照値より192％（投与後0分）, および166％（投与後5分）増大し, 冠血管抵抗は減少し, 心筋酸素摂取率は75.1％から47.9％（投与後5分）に低下した. 心筋外層血流量は内層より優位に増大したが, 心筋酸素消費量が不変であったため, transmural stealの状態ではないと考えられ, 良好な冠血流量の増大作用を示した. 腎血流量もまた増大傾向を示し, cinepazideによるこれらの臓器の血流増大作用が確認された. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Effects of cinepazide on coronary and renal circulation in dogs. |
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| Subtitle | |
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| Authors | Tomokazu Harada, Takeshi Sone, Ikuo Tsukahara, Harutaka Uematsu, Michio Yamamoto |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Gifu University, School of Medicine |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 2 |
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| Page | 215-219 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Effects of cinepazide, a vasoactive agent, at the dose of 10mg／kg／10 min. on coronary and renal circulation in anesthetized open chest dogs were studied. Cardiac output and Max dp／dt had the tendency to increase and total peripheral resistance had the tendency to decrease, while mean aortic pressure and heart rate remained constant on the average. These are indications of a positive inotropic effect of the drug. The marked increase in coronary blood flow and the marked decrease in coronary vascular resistance were observed, but the ratio of subendocardial−subepicardial blood flow had the tendency to decrease. Although these conditions suggest the possibility of subendocardial ischemia, the facts of significant decrease of myocardial oxygen extraction and no change in myocardial oxygen consumption neglect the possibility of transmural steal. The drug cinepazide acts mainly as a peripheral vasodilator, but is also to be classified among the so−called “coronary vasodilators of benign type”. |
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| Practice | Basic medicine |
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| Keywords | coronary circulation, myocardial blood flow, cinepazide |
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