| Japanese |
|---|
| Title | 心臓麻酔におけるくも膜下腔モルヒネ投与の応用 |
|---|
| Subtitle | |
|---|
| Authors | 舘田武志*, 金子敏雄*, 高尾弘*, 高橋俊一*, 山中郁男*, 高橋敬蔵*, 曾清楷** |
|---|
| Authors(kana) | |
|---|
| Organization | *聖マリアンナ医科大学麻酔学教室, **高雄医学院麻酔学教室 |
|---|
| Journal | 循環制御 |
|---|
| Volume | 9 |
|---|
| Number | 2 |
|---|
| Page | 227-232 |
|---|
| Year/Month | 1988/ |
|---|
| Article | 原著 |
|---|
| Publisher | 日本循環制御医学会 |
|---|
| Abstract | モルヒネを腰部くも膜下面に投与する事が術中の安定した循環動態・術後の鎮痛に有効と考え, 開心術の麻酔に応用しその効果を検討した. 定時心臓血管手術患者24例にモルヒネ2mgを腰部くも膜下腔に投与し, 麻酔の導入を行った（併用群）. 16例にモルヒネ静脈内投与のみで麻酔を行い, これを対照群とした. 併用群では対照群に較べ, モルヒネ静脈内総投与量は3分の1に減少したにもかかわらず, 挿管・胸骨切開時の循環動態は安定していた. 術後の抜管までの時間は併用群で延長したが, 統計学的には有意ではなかった. 鎮痛時間は併用群で術後34±12時間, 対照群で術後25±8時間と併用群で著明に延長した. 又, 併用群では術後に麻酔拮抗薬を投与されたものはいなかったが, 対照群では3例で投与された. 開心術におけるくも膜下腔のモルヒネ投与は大量モルヒネ麻酔に較べ, 術中の循環動態を安定させ, 術後の痺痛対策に有効であるが, 術中覚醒に対する配慮が必要と考えられた. |
|---|
| Practice | 基礎医学・関連科学 |
|---|
| Keywords | |
|---|
| English |
|---|
| Title | Intrathecal Administration of Morphine for Cardiac Surgery |
|---|
| Subtitle | |
|---|
| Authors | Takeshi Tateda, Toshio Kaneko, Hiroshi Takao, Shunichi Takahashi, Ikuo Yamanaka, Keizo Takahashi, Chin−Kai Tseng* |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Anesthesiology, St. Marianna University School of Medicine, *Kaoh−Shin Medical College, Kaoh−Shin, R. O. C. |
|---|
| Journal | Circulation Control |
|---|
| Volume | 9 |
|---|
| Number | 2 |
|---|
| Page | 227-232 |
|---|
| Year/Month | 1988/ |
|---|
| Article | Original article |
|---|
| Publisher | Japan Society of Circulation Control |
|---|
| Abstract | Hemodynamic changes and histamine release associated with intrathecal and intravenous administration of morphine were studied in 40 patients undergoing cardiovascular surgery. The cases were divided into two groups. In group A, 24 of patients were recieved morphine intravenously soon after the administration of 2mg morphine intrathecally. In group B, the patients were anesthetized with morphine intravenously only. Anesthesia was induced with small increments of i. v. morphine （5−10mg） and diazepam, until unconsciousness occured, followed by the administration of pancuronium and intubation. Hemodynamic measurements were recorded continuously and arterial blood samples were collected for determination of plasma histamine levels（radioimmunoassay）：pre−induction, post−incision and post−sternotomy. Patients in group B required more morphine intravenously than those in group A during operation （1.8±0.5mg／kg vs 0.5±0.2mg／kg）. |
|---|
| Practice | Basic medicine |
|---|
| Keywords | Analgesics： morphine, Anesthetic techniques： intrathecal, Anesthesia： cardiovascular, Histamine： release |
|---|