| English |
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| Title | Electrophysiologic Study of Sinus Node Function in Isolated Rabbit Sinoatrial Preparation |
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| Subtitle | |
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| Authors | WU Jianyi, SHIH YUshu |
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| Authors(kana) | |
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| Organization | From the Department of Cardiology, Second affiliated Hospital, Tianjin Medical College |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 2 |
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| Page | 239-248 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Using standard microelectrode techniques, this study investigated the affected factors for evaluating sinus node function and the effects of autonomic nervous system on sinus node function in 44 isolated rabbit sinuatrial preparations. We found that：1） Overdrive pacing directly depressed the pacemaker automaticity and SNRT dependent on the complex interactions among automaticity, conductivity and refractoriness in sinus node. 2） All indirected methods for estimating SACT might be affected by the depression of automaticity and the shift of primary pacemaker site. 3） Echo response would complicate the estimation of SNERP. 4） Besides the positive and negative effects of isoprenaline and acetylcholine separately, ATP decreased sinus rate by a reduction of phase 4 slope, increased SNERP by a lengthening of action potential duration, and had not significantly effect on SACT, which could not be modified by atropine. |
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| Practice | Basic medicine |
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| Keywords | Sinus node function, Electrophysiologic study, SNRT, SACT, SNERP |
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