| Japanese |
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| Title | 肝循環及び肝酸素代謝に対するトリメタファン, ATP, NTG 3者の比較 |
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| Subtitle | |
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| Authors | 影嶋和幸*, 正木英二*, 三間伸一*, 木村準**, 谷藤泰正*, 小林建一* |
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| Authors(kana) | |
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| Organization | *東京慈恵会医科大学麻酔科学教室, **日本文化厚生財団成人病医学研究所 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 3 |
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| Page | 335-340 |
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| Year/Month | 1988/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 今回, われわれは雑種成犬を用い, 1MACエンフルレン, 100％酸素麻酔下, ATP, NTG及びTMによるMAP 60mmHgの低血圧麻酔での肝循環及び肝酸素代謝に及ぼす影響について比較検討した. 結果として肝循環では肝動脈血流量は3者とも変化が認められず, 門脈血流量及び総肝血流量はNTG＜ATPの順で有意な増加, TMで有意な減少が認められた. 一方, 肝酸素代謝面では肝酸素消費量は3者とも変化が認められなかったが, 肝酸素供給量はNTG＜ATPの順で有意な増加, TMで有意な減少が認められた. 以上より肝広汎切除術及び肝移植術などの低血圧麻酔薬としては, 従来使用頻度の高いTM, NTGよりも, ATPの方が肝庇護の点でより優れた薬剤であることが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | A Comparison among Trimetaphan, Adenosine triphosphate and Nitroglycerin on Hepatic Circulation ahd Hepatic Metabolism |
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| Subtitle | |
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| Authors | Kazuyuki Kageshima*, Eiji Masaki*, Shinichi Mima*, Jun Kimura**, Yasumasa Tanifuji*, Kenichi Kobayashi* |
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| Authors(kana) | |
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| Organization | *The Jikei University School of Medicine, Department of Anesthesiology, **Aizu Research Institute for Adult Diseas |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 3 |
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| Page | 335-340 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Effects of hypotension anesthesia （MAP 60mmHg）by trimetaphan （TM）, adenosine triphosphate （ATP） or nitroglycerin （NTG） on hepatic blood flow and hepatic metabolism were studied in six mongrel dogs during 1MAC enflurane anesthesia. Hepatic artery and portal vein flows were measured by ultrasonic blood flowmetry. Hepatic oxygen supply and consumption were calculated from blood flows and oxygen contents. As results, hepatic arterial blood flow did not significantly change by the three drugs, but portal venous blood flow significantly increased by NTG＜ATP, significantly decreased by TM. Whereas hepatic oxygen consumption did not change by the three drugs, but hepatic oxygen supply significantly increased by NTG＜ATP, significantly decreased by TM. The results suggest that hepatic circulation and hepatic metabolism should be well maintained during ATP−induced hypotension compared with NTG- and TM-induced hypotension anesthesia. |
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| Practice | Basic medicine |
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| Keywords | trimetaphan, adenosine triphosphate, nitroglycerin, hepatic circulation, hepatic metabolism |
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