| Japanese |
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| Title | 咳誘発の心拍数増加反応による自律神経機能の評価 |
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| Authors | 土肥修司, 武島玲子 |
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| Organization | 筑波大学臨床医学系麻酔科 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 3 |
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| Page | 359-364 |
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| Year/Month | 1988/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 咳誘発による心拍数増加が自律神経系の機能を評価する試験となるかを検討するために, 健康志願者14名, 健康成人患者95名, 糖尿病患者30名を対象として検討した. 健康成人においては, 咳試験の結果（5秒以内に大きな咳を3回した後の心拍1数の増加）と年齢（14−85歳）との間には高い負の相関（n＝109, r＝-0.75）が得られ, 回帰直線はy＝36.24−0.426Xであった. 糖尿病患者における両者の相関係数は低かった（r＝30, r＝-0.44）. 38名の健康成人において検討した咳誘発による心拍数増加と昇圧及び降圧試験による動脈圧受容体反射の感受性（ms／mmHg）との間の相関係数は, それぞれ0.59と0.47であった. 自律神経障害を有する糖尿病患者では, 有しない患者と比較して, 咳による心拍数の増加が有意に抑制されていた（P＜0.01）. 咳誘発による心拍数増加は麻酔前の患者の自律神経機能を評価しうる簡便な試験となり得る. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Heart Rate Response To Coughing For Assessing Cardiac Autonomic Integrity In Normal and Diabetic Subjects |
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| Authors | Shuji Dohi, Reiko Takeshima |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Institute of clinical Medicine University of Tsukuba |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 3 |
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| Page | 359-364 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The heart rate response to cough has been suggested to be a noninvasive test for assessing cardiac autonomic integrity. In order to confirm this, we compared cardioacceleratory response to cough in 109 healthy individuals and 30 diabetic patients with or without autonomic neuropathy. In healthy individuals （14−85yrs of age）, there was a good correlation between their age and the increase in heart rate （ΔHR）, the linear regression equation obtrained was ΔHR＝36.24−0.426×age （n＝109, r＝−0.75）. In patients with diabetes, the correlation between them was lower （n＝30, r＝−0.44） than that of healthy patients, but the heart rate response in diabetic with autonomic neuropathy （0.8±1.2BPM, n＝10） was significantly less than that in those without autonomic neuropathy （4.8±2.9BPM, n＝20, p＜0.01）. The correlation coefficient between the cough−induced increase in heart rate （ΔHR） and the arterial baroreflex sensitivity was 0.59 for the pressor test and 0.47 for depressor test in 38 healthy adults. The results indicate that the cough test may be simple and useful for the evaluation of cardiac autonomic integrity in patients undergoing anesthesia and surgery. |
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| Practice | Basic medicine |
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| Keywords | Autonomic nervous activity, Heart rate, Cough, Diabetes mellitus, Baroreflex |
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