| Japanese |
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| Title | 脳虚血後60分目に投与されたニカルジピンの脳血流におよぼす影響 |
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| Subtitle | |
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| Authors | 岩月尚文, 小野勝彦, 高橋雅彦, 田島つかさ |
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| Authors(kana) | |
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| Organization | 東北大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 3 |
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| Page | 365-368 |
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| Year/Month | 1988/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 全脳虚血後再還流時に出現する脳血流の低下に対するカルシュウム拮抗薬の効果を, ニカルジピン（NC）を血流低下の発現すると推測される血流再開後60分目より投与し, 犬を用いて検討した. 虚血後面還流により一過性に上昇した脳血流は60分目にほぼ虚血前値に戻ったが, この時期よりのNC 10μg／kg bolus次いで1μg／kg／min 持続投与によってもさらにNC非投与時の値まで低下し, NCによる血流低下阻止効果は, 認められなかった. 血流低下阻止のためには, NCは血流低下成立前, 再還流後出来るだけ早期の投与が望ましい. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | Effects of Nicardipine Given 60 minutes after Recirculation upon Post−ischemic Cerebral Hypoperfusion in dogs |
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| Authors | Naofumi Iwatsuki, Katsnhiko Ono, Masahiko Takahashi, Tsukasa Tagima |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Tohoku University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 3 |
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| Page | 365-368 |
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| Year/Month | 1988/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Effects of nicardipine （NC） upon cerebral blood flow （CBF） were evaluated in dogs by giving NC 60 min after re−establishment of circulation. Ten minutes complete cerebral ischemia was induced by clamping of aorta and 10μg／kg of NC in bolus followed by infusion of 1μg／kg／min for 90 min was administered from 60 min after de−clamping of aorta. CBF which transiently increased immediately after recirculation gradually decreased and reached to the pre−ischemic level by 60 min. NC given at this time did not prevent the farther decrease in CBF（76％ of pre−ischemic value at 90 min after NC injection）. We thus conclude that the administration of NC at the time which CBF starts to decrease after cerebral ischemia is not effective to prevent the development of the post ischemic cerebral hypoperfusion. |
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| Practice | Basic medicine |
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| Keywords | Nicardipine, Post ischemic hypoperfusion. |
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