| Japanese |
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| Title | 深度別にみた各種吸入麻酔薬の肝血流, 肝酸素消費量への影響 |
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| Subtitle | シンポジウム「麻酔と肝・腎循環」 特集 |
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| Authors | 正木英二*, 影嶋和幸*, 安田信彦*, 谷藤泰正*, 木村準**, 小林建一* |
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| Organization | *東京慈恵会医科大学麻酔科学教室, **日本文化厚生財団成人病研究所 |
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| Journal | 循環制御 |
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| Volume | 9 |
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| Number | 4 |
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| Page | 459-464 |
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| Year/Month | 1988/ |
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| Article | 報告 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 要旨 肝血流と肝酸素消費量に及ぼす吸入麻酔薬の影響を, 雑種成犬12頭を用い検討した. 12頭を6頭ずつ2群に分け, 1群6頭に対しては, ハロセン, セボフルレン, イソフルレン1.0MAC下に, 2群6頭では, ハロセンを0.5−2.0MACの範囲で投与し各諸量を測定比較した. 肝動脈血流量, 門脈血流量は超音波トランジットタイム血流計にて, 平均動脈圧とともに連続的にモニターした. 3種麻酔薬1.0MAC下の比較で, イソフルレンは他2薬に比べ, 全身, 肝循環動態ともに増加傾向を示し, 特に肝酸素供給量, 肝静脈酸素含量ではハロセンに対し有意であった. 一方ハロセン麻酔下では麻酔深度とともに肝酸素供給量が減少し, 肝酸素消費量との間のバランスが保たれなくなった. 以上よりハロセンはイソフルレンに比べ, 肝循環動態を強く抑制し, 明らかに肝が低酸素状態に陥りやすく, さらにこの状態はハロセン麻酔深度が増すとともに著明となる傾向が示唆された. 序文 ハロセンは現在でも広く吸入麻酔薬として用いられているが, いくつかのハロセン麻酔後の肝障害が報告されている. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Effects of various volatile anesthetics and its anesthetic depth on hepatic blood flow and oxygen consumption |
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| Authors | Eiji Masaki, Kazuyuki Kageshima, Nobuhiko Yasuda, Yasumasa Tanifuji, Jun Kimura*, Kenichi Kobayashi |
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| Authors(kana) | |
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| Organization | The Jikei University School of medicine, Department of Anesthesiology, *Aizu Research Institute for Adult Disease |
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| Journal | Circulation Control |
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| Volume | 9 |
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| Number | 4 |
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| Page | 459-464 |
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| Year/Month | 1988/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Effects of halothane, sevoflurane and isoflurane at 1.0MAC on hepatic blood flow and oxygen consumption were compared in dogs. We also investigated effect of anesthetic depth of halothane（0.5−2.0MAC）in the present study. It was demonstrated that isoflurane maintained hemodynamic variables not only in the systemic （MAP, CI） but in the hepatic （HABF, PVBF, THBF）, comparing halothane and sevoflurane. There were significant differences on hepatic oxygen suuply and hepatic venous oxygen content between isoflurane and halothane. On the other hand, halothane significantly decreased hepatic oxygen supply in a dose dependent manner, therefore hepatic oxygen supply and consumption were out of balance with increasing concentration of halothane. The results of the present study suggest that halothane significantly inhibits hemodynamic variables in the liver and produces a change in balance toward hypoxia between hepatic oxygen supply and consumption with increase of anesthetic dose, comparing isoflurane. |
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| Practice | Basic medicine |
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| Keywords | volatile anesthetics, anesthetic depth, hepatic blood flow, hepatic oxygen consumption, hepatic oxygen supply |
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