| Japanese |
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| Title | 心拍変動に及ぼすセボフルレン／笑気麻酔の影響 |
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| Subtitle | |
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| Authors | 石川岳彦*, 木村智政**, 劔物修* |
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| Authors(kana) | |
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| Organization | *北海道大学医学部麻酔学教室, **名古屋大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 10 |
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| Number | 1 |
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| Page | 101-105 |
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| Year/Month | 1989/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 最近, 心拍変動の周波数解析から循環に対する自律神経系の調節能を評価する試みがある, 今回, この方法により新しい吸入麻酔薬であるセボフルレンの自律神経活動に与える影響について検討した. 7名の婦人科手術予定患者を対象とした. サイアミラールで麻酔導入後, サクシニルコリンにて気管内挿管し, セボフルレン1MAC／笑気50％で維持した. この後, 心電図波形からRR間隔の記録を開始し, コンピュータに連続的に取り込んだ. 取り込まれたデータは高速フーリエ変換され, 得られたパワースペクトルを導入前のそれと高域, 中域, 低域の周波数領域に3分割して比較・検討した. セボフルレン麻酔中のパワースペクトルは麻酔導入前に比較し, 全ての周波数領域で有意に低下していた. これは, 新しい吸入麻酔薬であるセボフルレンも, 従来報告のあった吸入麻酔薬と同様に交感・副交感神経の双方に対して著明な抑制効果を有することを示していた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | Influence of Sevoflurane／Nitrous Oxide Anesthesia. |
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| Subtitle | |
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| Authors | Takehiko Ishikawa*, Tomomasa Kimura**, Osamu Kemmotsu* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology, Hokkaido University School of Medicine, **Department of Anesthesiology, Nagoya University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 10 |
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| Number | 1 |
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| Page | 101-105 |
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| Year/Month | 1989/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Spectral analysis of heart rate variations has been current topics to evaluate the autonomic nervous activity oncirclation control. In this study, sevoflurane, a newly developed volatile anesthetic, is focused on and we evaluated the autonomic nervous activity on circulation control under the influence of this anesthetic. Seven adult females undergoing gynecological sugery were studied. The anesthetic management of these patients followed our standard procedure. Anesthesia in all the patients was induced with thiamylal （5mg／kg） i. v., intubated with succinylcholine （1mg／kg） i. v. and maintained with 1MAC sevoflurane in 50％ nitrous oxide. Time sequential heart periods （i. e. RR interval） were measured from output of the ECG monitor before and after anesthesia. Power spectral analysis of these data was computed using a fast Fourier transform. Based on the previous study, the computed power spectra were divided into 3 frequency areas；the low frequency area consists of 0.04−0.095Hz, the middle is 0.095−0.15Hz, the high is 0.15−0.30Hz. Statistical analysis （analysis of variance） showed signifcant decreases of any 3 frequency areas during sevoflurane／N2O anesthesia. In conclusion, sevoflurane has a potent suppressive effect on autonomic nervous activity as other inhalation anesthetics. |
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| Practice | Basic medicine |
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| Keywords | sevoflurane, heart rate variations, spectral analysis, autonomic nervous sytem |
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