| Japanese |
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| Title | ニトログリセリンとニコランジルの各種病態下での心・血管系に対する作用―一般術後症例, A−Cバイパス術症例, 冠動脈造影症例―についての比較検討 |
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| Subtitle | |
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| Authors | 久場良也 |
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| Authors(kana) | |
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| Organization | 鳥取赤十字病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 10 |
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| Number | 1 |
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| Page | 107-117 |
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| Year/Month | 1989/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | ニトログリセリン（NTG）とニコランジル（SG）の種々の病態下での心・血管系に対する効果を一般術後症例, A−Cバイパス術症例, 冠動脈造影症例にて比較検討した. NTGは優れた冠動脈拡張作用を示したが, 冠血流量の増加はみられず, 用量依存性に前負荷の軽減作用を示した. 一方, SGは冠動脈拡張作用においてNTGよりも劣るが, 体循環に影響を与えることなしに冠血流量の増加, 冠動脈拡張作用を示した. 以上のことより, NTGは冠動脈攣縮の発作時やうっ血性心不全の症例に有用であり, SGはA−Cバイパス術直後の不安定期におけるグラフト流量の維持や冠動脈攣縮の予防に適している. また, 低血圧状態においてはSGのほうがNTGよりも安全に使用し得るとおもわれた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | |
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| English |
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| Title | Comparative studies on cardiovascular effects of nitroglycerin and nicorandil during non−cardiac surgery, A−C bypass surgery and coronary angiography |
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| Subtitle | |
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| Authors | Yoshinari Kuba |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology, Tottori Red Cross Hospital |
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| Journal | Circulation Control |
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| Volume | 10 |
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| Number | 1 |
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| Page | 107-117 |
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| Year/Month | 1989/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Cardiovascular effects of nitroglycerin and nicorandil were studied in 7 patients for non−cardiac surgery（Part 1）, 18 patients for A−C bypass surgery （Part 2） and 20 patients for coronary angiography （Part 3）. In Part 1, hemodynamics were measured in the immediate post operative period. Nitroglycerin, administered at 4μg／kg／min for 5 min, decreased both preload and cardiac output, while nicorandil produced no significant changes in hemodynamics. In Part 2, the graft flow and other hemodynamics were measured after coming off the cardiopulmonary bypass. Nicorandil, administered at 50μg／kg／min for 5 min, significantly increased the graft flow, while nitroglycerin showd no effects. Nitroglycerin, administered at 20μg／kg／min for 2 or 3 min, dramatically decreased both mean arterial pressure and preload. In Part 3, the diameter of the coronary artery with ergonovine provocation and other hemodynamics were measured, before and after bolus administration of each drug into the valsalva sinus. |
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| Practice | Basic medicine |
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| Keywords | systemic hemodynamics, coronary blood flow, coronary artery dilation, nicorandil, nitroglycerin |
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