| Japanese |
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| Title | プロスタグランディンE1, ニトログリセリン, トリメタファンによる低血圧麻酔の右室機能への影響 |
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| Subtitle | 原著 |
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| Authors | 上田光男*, 片山勝之*, 佐藤賢一*, 仲田房蔵*, 柏野繁男*, 劔物修* |
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| Authors(kana) | |
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| Organization | *北海道大学医学部麻酔学講座 |
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| Journal | 循環制御 |
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| Volume | 10 |
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| Number | 2 |
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| Page | 269-274 |
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| Year/Month | 1989/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」低血圧麻酔時の右室機能, 右室容量を, 温度応答速度の速いサーミスタを装着した肺動脈カテーテルを用いて, プロスタグランディンE1(PGE1), ニトログリセリン(TNG), トリメタファン(TM)の3薬物で比較, 検討した. PGE1では右室前負荷への影響は少なく, 後負荷の減少により心拍出量は増加した. TNGでは右室前負荷への影響が強く, それに伴って心拍出量は減少した. TMでは右室前負荷, 後負荷に変化は認められなかった. 3薬物とも右室駆出率(RVEF)には変化が認められなかった. したがって, PGE1, TNG, TMによる低血圧麻酔時の循環動態の変化はこれまでの報告と同様であり, 駆出期の右室機能の指標であるRVEFに影響しなかったことより, 3薬物による低血圧麻酔時には収縮期の右室機能(収縮力)に与える影響は少ないと考えられる. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | deliberate hypotention, right ventricular function, right ventricular volume, tricular ejection fraction |
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| English |
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| Title | Effects of deliberate hypotention induced by prostagladin E1, nitroglycerin, or trimethaphan on right ventricular function in man |
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| Subtitle | |
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| Authors | Mitsuo Ueda, Katsuyuki Katayama, Ken-ichi Sato, Fusazou Nakata, Shigeo Kaseno, Osamu Kemmotsu |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology Hookaido University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 10 |
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| Number | 2 |
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| Page | 269-274 |
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| Year/Month | 1989/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Recent technical development have enabled us to measure right ventricular ejection fraction (RVEF) utilizing the modified pulmonary artery catheter equipped with fast-response thermistor and to caluculate the end-diastolic, end-systolic and stroke volume of right ventricle. RVEF is one of the indeces of ventricular function, and it is influenced not only by myocardial function but also by loading condition and heart rate. A hypotensive drug may affect the right ventricular volume and/or contractility. Therefore, we investigated the effects of deliberate hypotension induced by either prostaglandin E1 (PGE1), nitroglycerin (TNG), or trimethaphan (TM) on the right ventricular function, espescially on the right ventricular volume, with a modified pulmonary artery catheter equipped with fast-response (100 ms) thermister. PGE1 caused little change of the right ventricular end-diastolic volume index (RVEDVI) (=right ventricular preload) and reduced the pulmonary vascular resistance index (PVRI) (=right ventricular afterload) leading to an increase in stroke volume index (SVI) and cardiac index (CI). TNG significantly reduced the RVEDVI leading to a decrease in CI. However, TNG caused little change of the right ventricular afterload. TM affected neither of the right ventricular preload nor afterload. And, none of three drugs changed the right ventricular ejection fraction. Therefore, PGE1, TNG, TM induced hemodynamic changes is such as that preveously reported, we concluded that deliberate hypotension induced by either PGE1, TNG, or TM did not affect the right ventricular function. |
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| Practice | Basic medicine |
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| Keywords | deliberate hypotention, right ventricular function, right ventricular volume, tricular ejection fraction |
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