| Japanese |
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| Title | 全身麻酔の心筋虚血保護作用 -ハロセン麻酔とドロペリドール, フェンタニール麻酔の比較- |
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| Subtitle | 原著 |
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| Authors | 坂田正策*, 松本幸久*, 鳥海信一*, 斎藤隆雄**, 中原俊之*** |
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| Authors(kana) | |
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| Organization | *徳島大学医学部附属病院手術部, **徳島大学医学部附属病院麻酔科, ***徳島県立中央病院麻酔科 |
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| Journal | 循環制御 |
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| Volume | 11 |
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| Number | 1 |
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| Page | 73-78 |
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| Year/Month | 1990/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」ハロセン(H)およびドロペリドール, フェンタニール(D-F)麻酔下の開胸犬で冠狭窄による部分虚血の心筋代謝への影響を観察した. 冠狭窄で内層酸素分圧は両群とも低下したが, その程度はH群(4.9mmHg)よりD-F群(6.7mmHg)で大きい傾向にあった. 心筋乳酸摂取率はH群では対照時33.9%, 冠狭窄後36.6%と維持されていたのに対し, D-F群では32.6%から17.2%に低下した. 動冠静脈水素イオン濃度較差は両群とも有意に変化しなかったが, D-F群で著明に上昇する例がみられた. 心拍数, 大動脈血圧, 左室拡張終期圧は両群でほぼ同じ水準にあり, これらの循環動態と心筋代謝の変動には因果関係は認められなかった. 以上より, H麻酔はD-F麻酔に比較して虚血時の心筋代謝に有利に作用する可能性を持つと思われた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | partial ischemia, myocardial metabolism, anesthesia, hemodynamics |
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| English |
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| Title | Effects of Anesthesia on Myocardial Metabolism during Partial Ischemia Induced by Coronary Constriction in Dogs. Comparison of Halothane and Droperidol-Fentanyl. |
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| Authors | Seisaku Sakata, Shin-ichi Toriumi, Yulnhisa Matsumoto, Takao Saito, Toshiyulri Nakahara |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology Tokushima University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 11 |
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| Number | 1 |
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| Page | 73-78 |
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| Year/Month | 1990/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The effects of partial ischemia on myocardial oxygen balance and metabolism were observed under halothane (1.0-1.2% inhalation, n=14) and droperidol (0.5 mg/kg bolus) -fentanyl (75 μg/kg bolus, 0.75 μg/kg/min infusion) (n=14) anesthesias in dogs. Measurements were made before and after partial ischemia induced by constriction of the left circumflex coronary artery to a point at which resting flow decreased by about 10 per cent. Subendocardial oxygen pressure significantly decreased after coronary stenosis in both the halothane and the droperidol-fentanyl groups, though the extent of the decrease in the latter tended to be greater than that in the former. Myocardial lactate extraction ratio did not change significantly in the halothane group, while it significantly decreased in the droperidol-fentanyl group. Coronary arteriovenous hydrogen ion concentration difference increased more than twice the control value in none of animals in the halothane group, but in three from 14 animals in the droperidol-fentanyl group. The differences in these myocardial metabolic changes after coronary constriction between both groups could not be attributed to the hemodynamic state of heart rate, aortic blood pressure and left ventricular enddiastolic pressure, induced by anesthesia. From the results obtained in the study, it seemed probable that halothane anesthesia is more protective against myocardial partial ischemia than droperidol-fentanyl anesthesia, independent of their effects on hemodynamics. |
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| Practice | Basic medicine |
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| Keywords | partial ischemia, myocardial metabolism, anesthesia, hemodynamics |
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