| Japanese |
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| Title | 実験的心筋梗塞犬における, イソフルレン-笑気麻酔の循環動態ならびに心筋代謝に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 野村実 |
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| Authors(kana) | |
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| Organization | *東京女子医科大学麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 11 |
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| Number | 1 |
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| Page | 113-120 |
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| Year/Month | 1990/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」冠動脈前下行枝を結紮することにより心筋梗塞犬を作製し, 笑気50%併用下におけるイソフルレン1%および2%の循環動態ならびに心筋代謝を測定した. 正常心においては, 吸入濃度依存性に血圧, 心拍出量, 心筋組織血流量の低下が見られた. しかし, 心筋酸素摂取率, 心筋乳酸摂取率, 冠静脈洞乳酸・ピルビン酸比は有意に低下示し, 心筋代謝は保たれている考えられた. 虚血心においては, 正常心と同様に吸入濃度依存性に血圧, 心拍出量の低下が見られた. 心筋組織血流量は, 虚血部, 隣接部においてイソフルレン1%では変化がなかったが, 2%では軽度の低下が見られた. 心筋酸素摂取率は有意に低下を示した. 冠静脈洞乳酸・ピルビン酸比は上昇したが, 心筋乳酸摂取率には変化がなかった. 以上よりイソフルレンは, 虚血心において1%では心筋に及ぼす影響は少ないが, 2%では心筋代謝に虚血を生じる可能性がある. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | isoflurane, hemodynamics, myocardial metabolism, ischemic heart |
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| English |
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| Title | Effects of isoflurane-nitrous oxide anesthesia on hemodynamics and myocardial metabolism in experimentally produced myocardial ischemia by ligation of left anterior descending coronary artery in dogs. |
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| Subtitle | |
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| Authors | Minoru Nomura |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology Tokyo Women's Medical College |
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| Journal | Circulation Control |
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| Volume | 11 |
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| Number | 1 |
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| Page | 113-120 |
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| Year/Month | 1990/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We investigated the effects of isoflurane-nitrous oxide anesthesia on hemodynamics and myocardial metabolism in experimentally produced myocardial ischemia by ligation on left anterior descending ceronary artery in dogs. In normal heart, isofiurane descreased mean arterial pressure (MAP), cardiac output (CO) and systemic vascular resistance (SVR) in proportion with inspired concentration of isoflurane. Left ventricular stroke work decreased and EVR (DPTI/TTI) was maintained. Lactate extraction decreased, and lactate pyruvate ratio was unchanged. It was suggested that myocardial oxygen demand-supply was maintained. In ischemic heart, like normal heart, isoflurane decreased MAP, CO and SVR. But in concentration of 2% isoflurane, myocardial blood flow and EVR markedly decreased and lactate pyruvate ratio in coronary sinus increased significantly. It is likely that myocardial oxygen demand-supply is impaired. However changes in hemodynamics and myocardial metabolism during 1% isoflurane was minimum. It is concluded that isoflurane cause myocardial ischemia in ischemic heart during 2% isoflurane. |
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| Practice | Basic medicine |
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| Keywords | isoflurane, hemodynamics, myocardial metabolism, ischemic heart |
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