| Japanese |
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| Title | 人為的低血圧麻酔の腹部臓器血流に及ぼす影響 -とくにPGE1と他剤との比較- |
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| Subtitle | 原著 |
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| Authors | 岡本孝則*, 米田郁雄*, 内田和秀*, 佐藤哲雄*, 福島和昭* |
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| Organization | *防衛医科大学校麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 11 |
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| Number | 2 |
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| Page | 245-249 |
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| Year/Month | 1990/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」今回, われわれは笑気・酸素・筋弛緩薬麻酔下の雑種成犬を用いて, プロスタグランディンE1(PGE1)・ニトログリセリン(GTN)・トリメタファン(TMP)による収縮期血圧30%低下を目標とした低血圧麻酔において, 3剤が腹部臓器血流にどう影響を及ぼすか, 比較検討した. 上腸間膜動脈血流量はGTNでPGE1・TMPよりも高い傾向にあった. 門脈血流量はPGE1・TMPで対照値より有意な減少がみられ, GTNはTMPより高い傾向, PGE1より有意な高値を示した. 肝動脈血流量はPGE1で他より低い傾向がみられた. 総肝血流量はPGE1・TMPで対照値より有意な減少, GTNでPGE1・TMPより有意な高値を示した. 右腎動脈血流量はPGE1で対照値より有意に減少した. 以上, 低血圧麻酔時の腹部臓器血流維持の面で, 3剤のうちではGTNが有利であることが示唆された, また, PGE1ではあまり良い結果が得られなかった. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | hypotensive anesthesia, pharmacology, prostaglandin E1, nitroglycerin, trimetaphan, blood flow, abdominal vital organs |
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| English |
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| Title | The Effects of Controlled Hypotension lnduced by Prostaglandin E1, Nitroglycerin and Trimetaphan on The Blood Flow of the Abdominal Vital Organs |
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| Subtitle | |
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| Authors | Takanori Okamoto, Ikuo Yoneda, Kazuhide Uchida, Tetsuo Satoh, Kazuaki Fukushima |
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| Authors(kana) | |
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| Organization | National Defense Medical College Department of Anesthesiology |
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| Journal | Circulation Control |
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| Volume | 11 |
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| Number | 2 |
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| Page | 245-249 |
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| Year/Month | 1990/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We studied the effects of controlled hypotension (30% decrease in systolic arterial pressure) on the blood flow of the abdominal vital organs with prostaglandin E1 (PGE1), nitroglycerin (GTN) and trimetaphan (TMP) in six mongrel dogs under N2O and pancuronium anesthesia. We instrumented the dogs’with each appropriate electromagnetic probes on superior mesenteric artery (SMA), portal vein (PV), hepatic artery (HA) ang right renal artery (RA). GTN did not decrease SMA, PV, HA and total hepatic blood flow compared with the control, and had a tendency to be more than or a significant difference from PGE1 and TMP. PGE1 decreased RA blood flow significantly compared with the control. These results suggest that GTN is more beneficial to preserve the blood flow of the abdominal vital organs than PGE1 and TMP. |
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| Practice | Basic medicine |
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| Keywords | hypotensive anesthesia, pharmacology, prostaglandin E1, nitroglycerin, trimetaphan, blood flow, abdominal vital organs |
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