| Japanese |
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| Title | プロスタグランディンE1, ニトログリセリン, トリメタファンによる低血圧麻酔の腎機能に及ぼす影響 |
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| Subtitle | 原著 |
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| Authors | 堂崎信一*, 岡村篤*, 佐藤賢一*, 山村剛康*, 劔物修* |
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| Organization | *北海道大学医学部麻酔学講座 |
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| Journal | 循環制御 |
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| Volume | 11 |
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| Number | 3 |
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| Page | 327-332 |
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| Year/Month | 1990/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」低血圧麻酔に使用できる薬物の種類により, 低血圧麻酔中の腎機能に差があるかどうかを検索する目的で, 26例の腹部手術以外の手術症例で低血圧麻酔の適応のある患者を, プロスタグランディンE1(PGE1：14例), ニトログリセリン(TNG：5例)およびトリメタファン(TMP：7例)投与群の3例に分けた. 特注とも, 各薬物の投与前, 投与中の30分, 60分, および投与後の30分, 60分の時点で血中および尿中のα1-microglobulin(α1-M), β2-microglobulinca(β-M), N-acetyl-β-glucosaminidase(NAG)濃度と, クレアチニン・クリアランス(Ccr)を測定し, 比較検討した. 血中および尿中酵素濃度には各野間で差はなかったが, 投与中の30分におけるTNG群のCcrは, 他の2群に比較して有意に減少した(TNG 43±17ml/min, PGE1 104±15ml/min, TMP 107±18ml/min, mean±SEM, p<0.05). また, TMP群において投与後のβ2-MとNAGが異常高値を示した. これらの成績から, PGE1による低血圧麻酔では, TNGやTMPと比較して腎機能がよく保持されることが示唆された. また, 低血圧麻酔中の腎機能検査は, α1-Mやβ2-MよりもCcrおよびNAGの方が有用と思われた. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | hypotensive anesthesia, renal function, prostaglandin E1, trinitroglycerin, trimethaphan |
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| English |
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| Title | Renal Function during Controlled Hypotensive Anesthesia with either prostaglandinE1, trinitroglycerin or trimethaphan in Humans |
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| Subtitle | |
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| Authors | Shinichi Dozaki, Atsushi Okamura, Kenichi Sato, Takeyasu Yamamura, Osamu Kemmotsu |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology Hokkaido University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 11 |
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| Number | 3 |
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| Page | 327-332 |
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| Year/Month | 1990/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | It has been widely accepted that hypotensive anesthesia deteriorates renal function in humans. The comparative effects on renal function of prostaglandinE1 (PGE1), trinitroglycerin (TNG) and trimethaphan (TMP) were evaluated in 26 patients, who . were scheduled for hypotensive anesthesia after institutional approval and informed consent. Patients were divided into 3 groups, 14 patients for PGE1, 5 for TNG and 7 for TMP. Measurements of both plasma and urine αi-microglobulin (αi-M), β2-microglobulin (β2-M) and N-acetyl-β-glucosaminidase (NAG) concentrations together with creatinine clearance (Ccr) were performed at the following 5 points：before administration of either PGE1, TNG and TMP, 30 min and 60 min during administration of drugs, and 30 min and 60 min after cessation of drug administrations. While plasma and urine enzyme concentrations were not different between groups, Ccr value of TNG 30 min during administraion decreased significantly compared with other 2 groups (TNG 43±17 ml/min, PGE1 104±15 ml/min, TMP 107±18 ml/min, mean±SEM, p<0.05). Although there were no differences between groups, urine β2-M and NAG of TMP group increased more than normal limits after administration. These results indicate that PGE1 may not deteriorate renal function during hypotensive anesthesia, and that Ccr and NAG might be more useful renal functin tests than α1-M and β2-M during hypotensive anesthesia. |
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| Practice | Basic medicine |
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| Keywords | hypotensive anesthesia, renal function, prostaglandin E1, trinitroglycerin, trimethaphan |
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