| Japanese |
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| Title | 交感神経節におけるカテコールアミン受容体 -心拍数応答に対する交感神経活性の役割- |
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| Subtitle | 原著 |
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| Authors | 佐藤康弘**, 谷口興一***, 丸茂文昭* |
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| Organization | *東京医科歯科大学第2内科, **取手協同病院内科, ***東京医科歯科大学霞ヶ浦分院 |
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| Journal | 循環制御 |
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| Volume | 12 |
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| Number | 1 |
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| Page | 127-133 |
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| Year/Month | 1991/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」交感神経節における. 興奮伝導調節に関与するカテコールアミン(CA)受容体をin vivoで検討した. CAの交感神経節の興奮伝導に対する影響は交感神経節前線維の電気刺激により上昇した心拍数がCAによりどのように修飾されるかにより判断した. 交感神経節の栄養動脈に選択的にαアドレナリン, または, ドーパミン作動薬を投与したところ, 興奮伝導抑制はUK-14304(α2作動薬)が最も強く, 以下, Norepinephrine(NE), dipropyldopamine(DA2作動乱), dopamine(DA), phenylephrine(α1作動薬), fenoldopam(DA2作動薬)の順であった. α2遮断薬であるrauwolscineはNE, DAによる興奮伝導抑制に拮抗し, 単独で興奮伝導を増強した. DA2遮断薬domperidoneはDAの作用を減弱したが, NEには影響しなかった. また, 単独では, 興奮伝導を増強しなかった. DA1遮断薬SCH23390はNE, DAの作用に影響せず, 単独でも興奮伝導を増強しなかった. 以上の結果より, 1)交感神経節にはα2受容体とDA2受容体が存在するが, DA1受容体の存在は否定され, 2)交感神経節における興奮伝導調節に生理的に重要な役割を果たすのはα2受容体と考えられる. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | ganglionic neuro transmission, alpha adrenoceptor, DA1 dopamine receptor, DA2 dopamine receptor |
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| English |
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| Title | Catecholamine receptors in the autonomic ganglion -Role of sympathetic tone on regulation of the heart rate- |
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| Authors | Y.Satoh, K.Taniguichi, F.Marumo |
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| Authors(kana) | |
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| Organization | Department of 2nd Internal Medicine Tokyo Medical and Dental University |
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| Journal | Circulation Control |
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| Volume | 12 |
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| Number | 1 |
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| Page | 127-133 |
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| Year/Month | 1991/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | Roles of alpha adrenoceptors and dopamine receptors on the ganglionic neurotransmission were studied in the stellate ganglion of the pentobarbital-anesthetized dogs. Heart rate increased with preganglionic nerve stimulation (NS) and the changes in heart rate produced by the drugs during NS were examined. Agonists of the alpha adrenoceptors and dopamine receptors, injected into the artery perfusing the stellate gangion attenuated the increase in heart rate produced by NS and therefore inhibited the ganglionic neurotransmission. The order of potency interms of the inhibitory effect on the ganglionic neurotransmission was as follows ; UK14304 (alpha2)>norepinephrine (NE)>dipropyldopamine (DA2)>dopamine (DA)>phenylephrine (alpha1)>fenoldopam (DA1) ; alpha2 agonist was the most potent and DA1 agonist was the least. Moreover, rauwolscine, an alpha2 antagonist, augmented the increase in heart rate produced by NS, suggesting that it facilitated the ganglionic neurotransmission. Rauwolscine also antagonized the inhi’bitory effects of NE and DA on the ganglionic neurotransmission. Domperidone (a DA2 antagonist) did not modify the heart rate during NS, while it antagonized the effects of DA, but not NE. SCH23390 (a DA1 antagonist) had no effects on the increase in heart rate induced by NS or effects of NE and DA. These results suggest that there are alpha2 and DA2 receptors in the ganglion, in which alpha2 receptors seem to play physiological roles, and that there is no evidence to show the presence of DA1 receptors in the ganglion. |
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| Practice | Basic medicine |
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| Keywords | ganglionic neuro transmission, alpha adrenoceptor, DA1 dopamine receptor, DA2 dopamine receptor |
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