| Japanese |
|---|
| Title | 経時的臓器血液量の測定方法 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 福井明*, 濱田宏*, 木村健一*, 高折益彦* |
|---|
| Authors(kana) | |
|---|
| Organization | *川崎医科大学麻酔科学教室 |
|---|
| Journal | 循環制御 |
|---|
| Volume | 12 |
|---|
| Number | 1 |
|---|
| Page | 135-140 |
|---|
| Year/Month | 1991/ |
|---|
| Article | 原著 |
|---|
| Publisher | 日本循環制御医学会 |
|---|
| Abstract | 「要旨」VALMET社製局所脳血流測定装置BI1400を利用して, 臓器血液量の経時的測定を行うことを試みた. 臓器血液量の測定には, 検出器を測定する臓器に出来るだけ接近させて固定した. 99mTcでin vitro標識した赤血球を静脈内注入し, 各臓器の放射能値を測定した. 初回測定時間(Ho)のある臓器の放射能値をCo, ヘマトクリット値をHto, 臓器血液量を1とした. r分後のその臓器の放射能値を99mTcの半減期より, Ho測定時に補正し, これをCrとした. また, r分後のその臓器のヘマトクリット値をHtrとした. そして, r分後のその臓器の血液量変化を, HtoxCr/Htr×Coで表した, 今回の測定方法で生じた疑問点については, それぞれ以下のごとく対応した. 1)臓器血液量変化によって生じた臓器の形状, 検出器との距離の変化による測定値の誤差に対しては, 模擬臓器を用いて検討した. すなわち, 自由に変形可能な一定容量の模擬臓器に, 一定量の99mTcを入れ, 模擬臓器の形状, 検出器との距離, 検出器との角度を変化させて放射能値を測定した結果, その誤差は, 測定値の1%以下であって, 実質的には無視できるものと判断した. 2)測定臓器周囲からの放射線乱入の防御には, 鉛板にて対処した. 3)血液量変化を, より正確に測定するために, 検出器を正確に臓器に密着させる必要があることが認められた. |
|---|
| Practice | 基礎医学・関連科学 |
|---|
| Keywords | organ blood volume, continuous mesurements |
|---|
| English |
|---|
| Title | Continuous measurements of organ blood volume |
|---|
| Subtitle | |
|---|
| Authors | Akira Fukui, Hiroshi Hamada, Ken-ichi Kimura, Masuhiko Takaori |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Anesthesiology Kawasaki Medical School |
|---|
| Journal | Circulation Control |
|---|
| Volume | 12 |
|---|
| Number | 1 |
|---|
| Page | 135-140 |
|---|
| Year/Month | 1991/ |
|---|
| Article | Original article |
|---|
| Publisher | Japan Society of Circulation Control |
|---|
| Abstract | Organ blood volume was determined continuously using a local cerebroflowmeter (VALMET BI 1400). To determine the organ blood volume, the detector was fixed as near as possible to the organ. In vitro 99mTc-labelled erythrocytes were injected i.v. to begin determination of the radioactive value. The radioactive value, hematocrit value and blood volume of the organ at the starting time of determination (Ho) were expressed as Co, Htr and 1, respectively. Next, the radioactive value of each site after r minutes was corrected at Ho from the half-life of 99MTc, and this was expressed as Cr. The hematocrit value and time-course of the blood volume of the organ after r minutes were expressed as Htr and Hto×CrlHtr×Co, respectively. Possible errors occurring in the present method of measurements were dealt with in the following manner：1) For errors of determination due to changes in the shape of the organ and/or its distance from the detector caused by the time-course of the organ blood volume, we injected a definite amount of 99mTc into a morphologicaly free sham organ and held it by the detector. Thereby the radioactive value was determined from morphological changes in the sham organ. The determination at the time of sham change using the sham organ revealed the error to be not more than 1/100 of the determination value, which was judged as substantially negligible. 2) The organ was protected from radioactive intrusion by lead plates. 3) Close adhesion of the detector to the organ was considered necessary for more exact determination of the time-course. |
|---|
| Practice | Basic medicine |
|---|
| Keywords | organ blood volume, continuous mesurements |
|---|