| Japanese |
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| Title | ニトログリセリン(NG)静注が血漿カテコラミン濃度におよぼす影響 -NGがイヌ体抵抗血管と体容量血管におよぼす拡張作用の差の検討- |
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| Subtitle | 原著 |
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| Authors | 伊藤裕康*, 長田紀淳*, 湊口信也*, 佐橋照親*, 和田久泰*, 高井国之*, 越路正敏*, 平川千里* |
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| Authors(kana) | |
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| Organization | *岐阜大学医学部第2内科 |
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| Journal | 循環制御 |
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| Volume | 12 |
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| Number | 2 |
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| Page | 279-284 |
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| Year/Month | 1991/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」ペントバルビタール静注麻酔・開胸犬の無処置群と, ブピバカインをクモ膜下腔に注入して全脊髄麻酔を施した全脊髄麻酔群にニトログリセリン(NG)を静注した際, 無処置群では, 血圧低下に比例した用量依存性の血漿エピネフリン濃度増加を, また, 血漿ノルエピネフリン濃度にては用量依存性に増加する傾向を認めた. しかし, 全脊髄麻酔群においては血漿エピネフリン, ノルエピネフリン濃度に有意の変化を認めなかった. 無処置犬におけるNGの体容量血管拡張作用の程度は体抵抗血管拡張作用の程度よりも小であったが, 全脊髄麻酔下においては両者間に明らかな差を認めなかった(既報). この理由として, 無処置犬では, NGによって誘発された血圧低下→圧反射→全身交感神経緊張亢進→カテコラミン(CA)増加(特にエピネフリン)→CAの血管収縮作用が, NGによる体容量血管拡張を収縮的に修飾した結果であることが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | nitroglycerin, plasma catecholamine concentration, total spinal anesthesia, baroreceptor reflex |
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| English |
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| Title | Effects of the intravenous injection of nitroglycerin (NG) on plasma catecholamine concentration -A study of the differential dilator effect of NG on the systemic resistance and capacitance vessels in dogs- |
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| Subtitle | |
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| Authors | Hiroyasu Ito, Kijun Nagata, Shinya Minatoguchi, Teruchika Sahashi, Hisayasu Wada, Kuniyuki Takai, Masatoshi Koshiji, Senri Hirakawa |
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| Authors(kana) | |
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| Organization | The 2nd Department of Internal Medicine |
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| Journal | Circulation Control |
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| Volume | 12 |
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| Number | 2 |
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| Page | 279-284 |
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| Year/Month | 1991/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We studied two groups of open-chest dogs anesthetized with pentobarbital, i.e., untreated group and TSA group in which bupivacaine was injected into the subarachnoid space to produce total spinal anesthesia (TSA). In untreated group, plasma epinephrine concentration increased significantly in response to intravenous injection of nitroglycerin (NG) in proportion to the magnitude of decrease in blood pressure and in a dose-dependent manner, and plasma norepinephrine concentration tended to increase in the same manner. On the other hand, plasma norepinephrine and epinephrine concentrations did not change at all in TSA group. The degree of the vasodilator dffect of NG on systemic resistance vessels was more marked than that on systemic capacitance vessels in untreated group. By contrast, there was no significant difference in the effect of NG between systemic resistance and capacitance vessels in TSA group (previously reported). As an explanation for this dichotomy, we suggest that catecholamine (mainly epinephrine) was released by the baroreceptor reflex in response to a fall in blood pressure due to NG and the catecholamine-induced venoconstriction panially abolished the venodilator action of NG. |
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| Practice | Basic medicine |
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| Keywords | nitroglycerin, plasma catecholamine concentration, total spinal anesthesia, baroreceptor reflex |
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