| Japanese |
|---|
| Title | エンドトキシンショック時の各臓器血液量の経時的変化とメチルプレドニゾロン投与効果 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 福井明* |
|---|
| Authors(kana) | |
|---|
| Organization | *川崎医科大学麻酔科学教室 |
|---|
| Journal | 循環制御 |
|---|
| Volume | 12 |
|---|
| Number | 2 |
|---|
| Page | 305-313 |
|---|
| Year/Month | 1991/ |
|---|
| Article | 原著 |
|---|
| Publisher | 日本循環制御医学会 |
|---|
| Abstract | 「要旨」VALMET社製局所脳血流測定装置を応用し, エンドトキシンショック時の頭部, 胸部, 腹部, 大腿部の血液量の変化をほぼ連続的に120分にわたり, イヌを用いて測定した. すなわち, 全身麻酔後そのまま放置したC群, lipopolysaccharide 3mg/kgを静脈内投与したE群, ならびにlipopolysaccharide投与後直ちに, メチルプレドニゾロン30mg/kg投与したS群の3群でlipopolysaccharide投与開始後10, 20, 40, 60, 80, 100, 120分にそれぞれの血液量を測定した. この結果, 頭部, 大腿部の血液量はエンドトキシン投与120分間で有意な変化を認めなかった. 胸部では, 血液量の低下が認められたが, メチルプレドニゾロンによって, E群よりもその程度は軽度にとどまった. 腹部では, エンドトキシン投与後80分間にわたり血液滞留によると思われる血液量の増加が発生し, メチルプレドニゾロンによってその血液量増加が抑制された. しかし, エンドトキシン投与100, 120分後は反対に, E群, S群ともに軽度ではあったが減少した. |
|---|
| Practice | 基礎医学・関連科学 |
|---|
| Keywords | organ blood volume, endotoxic shock, methylprednisolone |
|---|
| English |
|---|
| Title | Changes in the blood volumes of the cephalic, thoracic, abdominal and femoral regions following endotoxin shock and effects of methylprednisolone |
|---|
| Subtitle | |
|---|
| Authors | Akira Fukui |
|---|
| Authors(kana) | |
|---|
| Organization | Department of Anesthesiology Kawasaki Medical School |
|---|
| Journal | Circulation Control |
|---|
| Volume | 12 |
|---|
| Number | 2 |
|---|
| Page | 305-313 |
|---|
| Year/Month | 1991/ |
|---|
| Article | Original article |
|---|
| Publisher | Japan Society of Circulation Control |
|---|
| Abstract | Using VALMET's cerebroflowmeter, the blood volumes of the cephalic, thoracic, abdominal and femoral regions in dogs were measured at one minute intervals over a period of two hours after intravenous injection of 3 mg/kg of endotoxin (E.coli 0111 B4). The dogs, anesthetized with pentobarbital sodium, were divided into three groups. In the C group, five animals were left in place without treatment througout the experiment. In the E group, nine animals were given 3 mg/kg of lipopolysaccharide. In the S group, nine animals were given 30 mg/kg of methylprednisolone immediately after the above i.v. injection of lipopolysaccharide. The respective blood volumes were measured at 10, 20, 40, 60, 80, 100 and 120 minutes after the i.v. administration of lipopolysaccharide. Cephalic and femoral blood volumes showed no significant change during 120 minutes after the i.v. administration of lipopolysaccharide. Thoracic blood volume was decreased after the i.v. administration of lipopolysaccharide alone, but was minimized by the administration of methylprednisolione. Abdominal blood volume increased markedly, which was probably due to blood pooling, and remained over a period of 80 minutes after the i.v. administration of endotoxin. However, this increase was minimized againd by methylprednisolone. On the other hand, at 100 and 120 minutes following the i.v. administration of endotoxin, the abdominal blood volume decreased slightly but significantly in both the E and S groups. |
|---|
| Practice | Basic medicine |
|---|
| Keywords | organ blood volume, endotoxic shock, methylprednisolone |
|---|