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| Title | Effects of inhalational anesthetics and verapamil on atrioventricular conduction in dogs -A comparative study of halothane, enflurane, isoflurane, and sevoflurane- |
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| Subtitle | Original |
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| Authors | Sho Yokota*, Chizuko Takigawa*, Isao Nakamura*, Osamu Kemmotsu* |
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| Authors(kana) | |
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| Organization | *Department of Anesthesiology Hokkaido University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 12 |
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| Number | 2 |
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| Page | 323-329 |
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| Year/Month | 1991/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」The interactions of halothane, enflurane, isoflurane, and sevoflurane with verapamil on atrioventricular (AV) nodal function were evaluated in dogs during atrial pacing. Thirty-four mongrel dogs were divided into five groups. Anesthesia was induced with ketamine and thihmylal and maintained with the following agents ; 0.8% halothane, 1.6% enflurane, 1.2% isofiurane, or 1.7% sevoflurane with 50% nitrous-oxide in oxygen. We observed interactions between inhalational anesthetics and sequential iv administration of verapamil 0.01, 0.02, 0.07 mg/kg. Five dogs in control group (C) received verapamil in the same manner without inhalational anesthetic. There were prolongations of sinus cycle length (SCL) and functional refractory period (FRP) of the AV node after each anesthetic. SCL and FRP were further prolonged in a dose dependent manner after iv administration of verapamil. There was no difference of magnitude of prolongation due to verapamil between each anesthetic group and group C. In conclusion, all inhalational anesthetics studied and verapamil had additive interaction on AV conduction. |
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| Practice | Basic medicine |
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| Keywords | Anesthetics, Volatile, enfiurane, halothane, isoflurane, sevoflurane, Heart, conduction, atrio-ventricular, Pharmacology, verapamil |
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