| Japanese |
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| Title | ACE阻害剤(captopril)が圧反射を惹起しがたい理由 -ウサギにおけるnoradrenaline release rateからの検討- |
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| Subtitle | 原著 |
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| Authors | 湊口信也*, 伊藤裕康*, Henryk Majewski** |
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| Organization | *岐阜大学医学部第2内科, **University of Melbourne |
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| Journal | 循環制御 |
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| Volume | 12 |
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| Number | 3 |
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| Page | 459-463 |
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| Year/Month | 1991/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」ACE阻害剤であるcaptopril(CAP)が圧反射を起こしにくい機序に検討を加えた. ウサギを用い, ペントバルビタール麻酔下と除神経電気刺激下にて, 3H-noradrenaline(NA)を頚動脈から一定の速度で注入, 血漿3H-NA濃度と血漿NA濃度を測定することにより, CAP(1mg/kg, CAP群, n=7), sodium nitroprusside(7μg/kg/min, SNP群, n=7), 生理食塩水(Saline群, n=8)投与前後において, NA release rate(NRR)を求めた. その結果, CAP群とSNP群の血圧低下はほぼ同程度であったが, NRRの%増加率は, Saline群≒CAP群<SNP群であり, Saline群とCAP群で検討した除神経電気刺激下のNRRにおける%変化率は, Saline群>CAP群であった. CAPが圧反射を惹起しがたい理由の一つとして, CAPが交感神経末端からのNA遊出減少をもたらすためであることが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | noradrenaline release rate, ACE inhibitor (captopril), baroreceptor reflex, plasma noradrenaline concentration, pithed rabbit |
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| English |
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| Title | The reason why ACE inhibitors (captopril) blunt baroreflex -Study with measurements of noradrenaline release rate in rabbits- |
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| Subtitle | |
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| Authors | Shinya Minatoguchi*, Hiroyasu Ito*, Henryk Majewski** |
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| Authors(kana) | |
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| Organization | *The 2nd Department of Internal Medicine School of Medicine, **University of Melbourne |
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| Journal | Circulation Control |
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| Volume | 12 |
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| Number | 3 |
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| Page | 459-463 |
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| Year/Month | 1991/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | We investigated the mechanism by which captopril (CAP), an ACE inhibitor, blunts baroreflex. Noradrenaline release rate (NRR) was measured before and after the administration of CAP (1 mg/kg, CAP group, n=7), sodium nitroprusside(7 μg/kg/min, SNP group n=7) or physiological saline (Saline group, n=8) in both anaesthetized and pithed rabbits. Under anaesthetized condition, NRR (pertcent change) was greater in SNP group than in Gifu University CAP group in spite of the fact that blood pressure fell almost to the same extent in SNP and CAP groups. Under pithed condition in which baroreflex was not present, NRR was decreased signifintly in CAP group than in Saline group. These results suggest that one of the mechanisms whereby CAP blunts baroreceptor reflex was that CAP secondarily decreased NRR from sympathetic nerve endings. |
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| Practice | Basic medicine |
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