Japanese
Titleハロセンとイソフルレンによる低血圧麻酔の血行動態に及ぼす影響
Subtitle原著
Authors武田昭平*, 稲田豊*, 中溝玲恵*, 池田東美明*, 外丸輝明*, 根岸秀**, 細山田明義**
Authors(kana)
Organization*昭和大学藤が丘病院麻酔科, **昭和大学医学部麻酔科学教室
Journal循環制御
Volume12
Number3
Page483-489
Year/Month1991/
Article原著
Publisher日本循環制御医学会
Abstract「要旨」雑種成犬を用い, ハロセン(H群)とイソフルレン(I群)の1MACの定常状態から吸入麻酔濃度を増加させ, 平均動脈圧60mmHgの低血圧麻酔を施行し, 血行動態に及ぼす影響を比較検討した. 低血圧中の血圧低下は, I群では体血管抵抗の低下を, H群では心係数の低下を伴い, 平均動脈圧は両群で有意に低下した. 低血圧終了後には, I群では対照値まで回復したが, H群では有意な低下が持続した. 左室dp/dt maxは両群で有意に低下したが, H群で抑制が強く, 左室拡張終期圧と鏡面像を呈した. 心拍数は両群で有意に減少したが, I群の減少が強かった. 心係数はH群で有意に低下した. I群では低下が軽度で有意な変動でなかった. 体血管抵抗はI群で有意に低下したが, H群では不変であった. I群では平均肺動脈圧, 肺動脈楔入圧, 肺血管抵抗は不変であった. H群では肺動脈楔入圧は有意に増加し, 肺血管抵抗は漸増した. 以上の結果より, 降圧機序はハロセンでは心筋抑制作用, イソフルレンでは血管拡張作用であった. また, 肺循環系はイソフルレンではハロセンに比較して影響が少ないことが示唆された.
Practice基礎医学・関連科学
Keywordsinduced hypotension, hemodynamics, halothane, isoflurane
English
TitleComparative Hemodynamic Effects of Controlled Hypotension Induced by either Halothane or Isoflurane in Dogs
Subtitle
AuthorsShohei Takeda*, Yutaka Inada*, Narue Nakamizo*, Tomiaki Ikeda*, Teruaki Tomaru*, Hideru Negishi*, Akiyoshi Hosoyamada**
Authors(kana)
Organization*Department of Anesthesiology Showa University Fujigaoka Hospital, **Showa University School of Medicine
JournalCirculation Control
Volume12
Number3
Page483-489
Year/Month1991/
ArticleOriginal article
PublisherJapan Society of Circulation Control
AbstractThe purpose of this study was to compare the hemodynamic effects of hypotension induced either by halothane or by isoflurane. Mongrel dogs were anesthetized with pentobarbital intravenously. They were randomly divided into two groups. Halothane group (n=8) received 0.87% halothane in oxyge, wheras isoflurane group (n=8) received 1.27% isoflurane in oxygen. After at least one hour stabilization of hemodynamics, the inspired concentrations of halothane or isoflurane were increased to lower mean arterial pressure (MAP) to 60 mmHg, which was maintained for 60 min. During and after induced hypotension, MAP in both groups was signifcantly lower than control values. Although MAP gradually retured toward control value in isoflurane group, siginificantly prolonged hyotension observed in halothane group. Changes in heart rate(HR)were similar in both groups. HR significantly decreased during and after induced hypotension in two groups. Cardiac index (CI) initially decreased but retured to control levels by the end of the experiment in isoflurane group. However, in halothane group, CI was significantly reduced by more than 50% of the control value at 30 and 60 min during induced hypotension. Systemic vascular resistance (SVR) was unchanged throughout the experiment in halothane group. In contrast, in isoflurane group, SVR was significantly decreased during induced hypotension and promptly returned toward control value after induced hypotension. Pulmonary vascular resistance (PVR) in isoflurane group was unchanged during and after induced hypotension. PVR in halothane group increased and was restored at 30 min after induced hypotension. Left ventricular maximum dp/dt (LV dp/dt max) decreased significantly during hypotension in both groups, but it increased rapidly to control values after hypotension in isofiurane group, but not in halothane group. In conclusion, our data indicate that isoflurane is preferable anesthetic in controlled hypotension because cardiovascular depression by isoflurane is less than halothane and because isoflurane is a potent systemic vasodilator as other investigetors pointed out.
PracticeBasic medicine
Keywordsinduced hypotension, hemodynamics, halothane, isoflurane

【全文PDF】