| Japanese |
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| Title | ACE阻害剤(captopril)の血管拡張作用に対する圧反射の影響 -Captopril, nitroglycerin, milrinoneの比較- |
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| Subtitle | 原著 |
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| Authors | 和田久泰*, 伊藤裕康*, 湊口信也*, 長田紀淳*, 佐橋照親*, 高井国之*, 瀬川知則*, 平川千里* |
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| Organization | *岐阜大学医学部第2内科 |
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| Journal | 循環制御 |
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| Volume | 13 |
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| Number | 1 |
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| Page | 97-102 |
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| Year/Month | 1992/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」Pentobarbital麻酔・開胸犬を, (1)全脊髄麻酔(TSA)を施して圧反射を除去したTSA群と, (2)TSAを施していない無処置群の2群に分け, 無処置群の平均血圧を約25%低下させる用量のnitroglycerin(NG ; 12.5μg/kg), milrinone(ML ; 100μg/kg), captopril(CP ; 1mg/kg)を静注した. その際生ずる全循環充満平均圧(MCP)の変化から体容量血管に対する作用を, また, 全末梢抵抗(TPR)の変化から体抵抗血管に対する作用を推定し, 2群を比較して各薬剤の血管拡張作用に対する圧反射の修飾を検討した. NGとMしの体容量血管拡張作用は, TSA群に比べ, 無処置群において有意に小さく, その作用は圧反射により減弱していることが示された. 一方, 体抵抗血管拡張作用は2群間に差を認めなかった. これとは対照的に, CPによる血管拡張作用は体容量血管と体抵抗血管ともに2群間で差を認めず, CPは圧反射を誘発し難い薬剤であることが示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | Baroceptor reflex, captopril, nitroglycerin, milrinone, systemic capacitance vessel |
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| English |
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| Title | Influence of baroceptor reflex on vasodilator action of ACE inhibitor (captopril), a comparison between captopril, nitroglycerin and milrinone |
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| Authors | Hisayasu Wada, Hiroyasu Ito, Shinya Minatoguchi, Kijun Nagata, Teruchika Sahashi, Kuniyuki Takai, Tomonori Segawa, Senri Hirakawa |
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| Organization | The 2nd Department of Internal Medicine Gifu University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 13 |
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| Number | 1 |
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| Page | 97-102 |
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| Year/Month | 1992/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | To evaluate the effects of baroceptor reflex on vasodilator action of nitroglycerin (NG, 12.5 μg/kg), milrinone (ML, 100 μg/kg) or captopril(CP, 1 mg/kg), we examined the dilation of systemic resistance and capacitance vessels induced by these drugs in both (1) TSA group where the total spinal anesthesia (TSA) was done to eliminate baroceptor refiex and (2) the untreated group without TSA. The doses of each drug used in this study were those required to decrease the mean blood pressure by about 25% in the untreated group. We estimated the dilation of the systemic capacitance and resistance vessels from a fall in the mean circulatory pressure and that in the total peripheral resistance, respectively, and comparisons were made between TSA and untreated groups. The vasodilator effects of NG or ML on the systemic capacitance vessels in TSA group were greater than those in the untreated group, but there was no significant difference in the vasodilator effects of NG or ML on the systemic resistance vessels between 2 groups. There was no significant difference in the vasodilator effects of CP on the systemic capacitance and resistance vessels between 2 groups. These results suggest that CP hardly induces baroceptor reflex. |
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| Practice | Basic medicine |
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| Keywords | Baroceptor reflex, captopril, nitroglycerin, milrinone, systemic capacitance vessel |
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