| English |
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| Title | Protection of the ischemic heart: a possible role for phospholipase inhibitors? |
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| Subtitle | (special edition) International Symposium on Ischemic Heart and Anesthesia |
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| Authors | Ger J.van der Vusse, Robert S.Reneman |
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| Organization | Department of Physiology,Cardiovascular Research Institute Maastricht,University of Limburg |
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| Journal | Circulation Control |
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| Volume | 13 |
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| Number | 3 |
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| Page | 357-372 |
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| Year/Month | 1992/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Introduction」Ischemia- and reperfusion-induced damage of the heart is a multifactorial process1). A variety of events, including disturbances in ion-homeostasis, acidification of the cellular milieu, depletion of high-energy phosphate stores, physical and chemical changes in the membranes enclosing the cell and its subcellular organelles, activation of lysosomal enzymes, and decreased capacity to scavenge endogenous oxygen free radials, most likely contribute to the loss of cell viability during the ischemic attack. Reperfusion of the previously ischemic area, although meant to prevent the cardiac cells from an inevitable death, may add to the ischemia-induced injury. Increased production of oxygen free radicals, enhancement of the cellular Ca2+-content resulting in myofibrillar contracture and activation of Ca2+-dependent hydrolases, and osmotic load are thought to be specific mechanisms of reperfusion-induced damage. Despite several decades of scrutinous investigation our knowledge of mechanisms underlying the loss of cell viability due to ischemia and reperfusion is still incomplete. |
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| Practice | Basic medicine |
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