| English |
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| Title | Changes in Myocardial Ischemic Areas by Anesthesia -Thermographic Determination- |
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| Subtitle | (special edition) International Symposium on Ischemic Heart and Anesthesia |
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| Authors | Sho Yokota, Yasuhisa Mayumi, Takehiko Ishikawa, Takeyasu Yamamura, Osamu Kemmotsu |
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| Organization | Department of Anesthesiology and Intensive Care,Hokkaido University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 13 |
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| Number | 3 |
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| Page | 389-394 |
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| Year/Month | 1992/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Abstract」We developed a computerized experimental system that can observe the size of ischemic area of a beating heart using thermography. The ischemic area defined by this system is named TDMIA; Thermographically Determined Myocardial Ischemic Area. This system includes monitoring and filing of heart rate, arterial, pulmonary arterial, and central venous pressures, cardiac output, myocardial pH, end-tidal CO2, anesthetic gas concentrations and temperatures. In the first experiment, we compared the effects of enflurane and isoflurane on TDMIA in swine utilizing this system. When the anesthetic concentration was changed from 1 MAC to 0.5 MAC, TDMIA decreased significantly together with increases in cardiac output and blood pressure. TDMIA also increased when the anesthetic concentration of either isoflurane or enflurane was increased. We found no significant differences in TDMIA changes between enflurane and isoflurane anesthesia. In conclusion, we advance the theory that isoflurane might have a coronary steal effect and that it might not be different from enflurane. In the second experiment, the possible beneficial effect of nitroglycerin to ischemic areas in the canine model was evaluated with and without dopamine infusions. Nitroglycerin alone (0.5μg/kg/min and 1μg/kg/min) had no effect on TDMIA compared to control dogs. Nitroglycerin at 1μg/kg/min with dopamine (7.5μg/kg/min) significantly decreased TDMIA. We speculated that the dilating effect of nitroglycerin on the coronary arteries interacted with the positive inotropic effect of dopamine in this experimental method. We conclude that nitroglycerin combined with dopamine would have benificial effects on myocardial ischemic areas in the early phase of acute myocardial infarction in the canine model. |
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| Practice | Basic medicine |
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