| English |
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| Title | Effects of Inhalation Anesthetics on Myocardial Energy Metabolism in the Ischemic Heart |
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| Subtitle | (special edition) International Symposium on Ischemic Heart and Anesthesia |
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| Authors | Satoshi Kashimoto, Takeshi Oguchi, Toshihiro Nakamura, Toshiaki Yamaguchi, Teruo Kumazawa |
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| Organization | Department of Anesthesiology,Yamanashi Medical College |
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| Journal | Circulation Control |
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| Volume | 13 |
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| Number | 3 |
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| Page | 395-403 |
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| Year/Month | 1992/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Introduction」It has been reported that reperfusion of ischemic myocardium causes reperfusion injury1,2). On the other hand, inhalation anesthetics have been reported to exert a protective effect against ischemic myocardium3-9). Therefore, we have previously investigated the effects of inhalation anesthetics on myocardial energy metabolism during postischemic reperfusion in the rats10-12). The present communication will first give two brief results from the isolated rat's heart. The possible mechanisms of protective effects of inhalation anesthetics will then be discussed. 「Methods 1 (Heart-lung preparation)」Forty male Wistar-Kyoto rats were anesthetized with 50mg/kg of pentobarbital intraperitoneally. A tracheostomy was performed. Cannulae were inserted into the aorta and the superior and inferior venae cavae. This preparation was perfused with a solution containing red blood cells collected from another rat and Krebs Ringer bicarbonate buffer with hematocrit and pH of 25% and 7.4, respectively. |
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| Practice | Basic medicine |
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| Keywords | |
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