| English |
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| Title | Myocardial free fatty acids during ischemia and reperfusion |
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| Subtitle | (special edition) International Symposium on Ischemic Heart and Anesthesia |
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| Authors | Yoshihisa Nasa |
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| Authors(kana) | |
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| Organization | Department of Pharmacology,Tokyo College of Pharmacy |
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| Journal | Circulation Control |
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| Volume | 13 |
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| Number | 3 |
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| Page | 413-426 |
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| Year/Month | 1992/ |
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| Article | Report |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | 「Contents」[1. Introduction][2. Ischemic injury and reperfusion injury][3. Determination of myocardial free fatty acids(FFA)][4. FFA in aerobic heart and ischemic heart][5. Phospholipids(PL) and triacylglycerol(TG) in ischemic heart][6. Relationship between high energy phosphates and FFA in ischemic heart][7. PL as a source of FFA accumulated during ischemia][7-1 ATP:AMP ratio and acyl-CoA synthetase][7-2 lysophospholipid acyltransferase][8. Accumulation of FFA during Reperfusion][9. Contribution of phospholipase to breakdown of PL and accumulation of FFA][9-1 Phospholipase A2 activity][9-2 Phospholipase C activity][10. Lipid peroxidation and reperfusion injury][11. Cardioprotection and myocardial FFA][12. Conclusions Acknowledgment References]「1. Introduction」Accumulation of tissue free fatty acids(FFA) occurs in the ischemic heart and its relation to severity of ischemic cell damage has been describedl1,32,57). Studies with isolated, perfused hearts have revealed that the myocardial levels of FFA increase markedly not only during ischemia but also during post-ischemic reperfusion4,22,43,57,58). |
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| Practice | Basic medicine |
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| Keywords | Free Fatty Acids (FFA), Ischemia, Reperfusion, Arachidonic acid, ATP:AMP ratio, Phospholipase, Plasmalogen, Cardioprotection |
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