| Japanese |
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| Title | 血液ガスおよび呼気ガス分析からみた血管拡張薬の呼吸・循環作用―ニトログリセリンとプロスタグランディンE1の比較― |
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| Subtitle | 原著 |
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| Authors | 坂田正策*, 松本幸久*, 加藤道久**, 樋口精一*, 斎藤隆雄* |
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| Organization | *徳島大学医学部附属病院手術部, **徳島大学医学部附属病院集中治療部 |
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| Journal | 循環制御 |
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| Volume | 13 |
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| Number | 3 |
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| Page | 463-467 |
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| Year/Month | 1992/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」臨床患者で血液および呼気ガス分析よりニトログリセリン5μg/kg/min(TNG)とプロスタグランディンE1 100ng/kg/min(PGE1)の血行動態および肺ガス交換への影響を比較した. 収縮期および拡張期血圧は両者で低下し, それらの低下度は等しかった. 肺胞−動脈血酸素分圧較差の増加はPGE1よりTNGで大きい傾向にあった. PaCO2はTNGでは有意に変化しなかったが, PGE1では上昇した. 動脈−終末呼気炭酸ガス分圧較差の拡大もPGE1よりTNGで強かった. 以上, TNGはPGE1と同様に抵抗血管にも強く作用すると思われた. TNGは心拍出量を減少, PGE1はこれを増加あるいは維持することが, また肺ガス交換への影響はTNGがPGE1より大きいことが推定された. |
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| Practice | 基礎医学・関連科学 |
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| English |
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| Title | Effects of Nitroglycerin and Prostaglandin E1 on Hemodynamics and Pulumonary Gas Exchange |
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| Authors | S.Sakata, Y.Matsumoto, M.Kato, S.Higuchi, T.Saito |
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| Organization | Department of Surgical Center,Tokushima University School of Medicine |
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| Journal | Circulation Control |
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| Volume | 13 |
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| Number | 3 |
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| Page | 463-467 |
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| Year/Month | 1992/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | In recent studies, the changes in arterial and end-tidal carbon dioxide tensions have been reported to correlate linearly with changes in cardiac output during the constant minute ventilation. High and low ventilation to perfusion mismatch can be also estimated from blood and expiratory gas analysis. In the present study, the effects of nitroglycerin (TNG) and prostaglandin E1 (PGE1) on hemodynamics and pulmonary gas exchanges were investigated by analyzing these gas tensions in nine sevoflurane/nitrous oxide-anesthetized patients. Decreases in systolic and diastolic blood pressures during TNG administration were almost identical to those during PGE1 administration. Arterial carbon dioxide tensions did not change significantly during TNG administration, but increased during PGE1 administration. Both alveolar-arterial oxygen tension differences and arterial-end-tidal carbon dioxide tension differences extended more widely during TNG administration than during PGE1 administration. In our study, TNG 5μg/kg/min seems to dilate resistance vessels as well as capacitance vessels as does PGE1 100ng/kg/min. It is concluded that TNG decreases cardiac output, whereas PGE1 increases or at least maintains it, and that TNG impairs pulmonary gas exchanges more than PGE1. |
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| Practice | Basic medicine |
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