| Japanese |
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| Title | 低血圧麻酔中の麻酔深度が代謝系に及ぼす影響―トリメタファンとニトログリセリンの比較検討― |
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| Subtitle | 原著 |
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| Authors | 小堀正雄, 信太賢治, 細山田明義 |
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| Organization | 昭和大学医学部麻酔学教室 |
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| Journal | 循環制御 |
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| Volume | 13 |
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| Number | 3 |
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| Page | 469-475 |
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| Year/Month | 1992/ |
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| Article | 原著 |
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| Publisher | 日本循環制御医学会 |
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| Abstract | 「要旨」鼓室形成術予定患者を対象にトリメタファン(TMP), ニトログリセリン(TNG)で低血圧麻酔を行い, この時の麻酔深度が代謝系に及ぼす影響を検討した. TMP, TNGそれぞれを麻酔深度でA群(GO＋ハロセン1％), B群(GO＋ハロセン0.5％)に分け, 4群間で検討した. 低血圧薬の平均使用量はTMP, TNGともB群のほうが有意に高かった. 低血圧中の循環動態は4群間でほとんど差が認められなかった. 血中乳酸値はすべての群で有意に上昇した. 乳酸・ピルビン酸比(L/P)はTMP-A群は有意差はなかったが, 他の3群は有意に上昇し, とくにTNG-B群の上昇が著しかった. 血糖値はTMP-A, B群に比べ, TNG-A, B群の上昇が目立った. 一方, 遊離脂肪酸はTNG-A, B群で有意に上昇したが, TMP-A, B群では変化が認められなかった. 低血圧麻酔を行う際, TMPのほうがTNGより代謝系に及ぼす影響が小さく, TNGによる低血圧麻酔のほうが術中の麻酔深度調節が重要である可能性が示唆された. |
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| Practice | 基礎医学・関連科学 |
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| Keywords | induced hypotensive anesthesia, trimethaphan, trinitroglycerin, metabolic respons, anesthetic depth |
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| English |
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| Title | Effects of the anesthetic depth on the metabolic response during induced hypotensive anesthesia, a comparison between trimethaphan and trinitroglycerin |
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| Subtitle | |
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| Authors | Masao Kobori, Kenji Shida, Akiyoshi Hosoyamada |
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| Authors(kana) | |
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| Organization | Department of Anesthesiology,School of Medicine,Showa University |
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| Journal | Circulation Control |
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| Volume | 13 |
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| Number | 3 |
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| Page | 469-475 |
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| Year/Month | 1992/ |
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| Article | Original article |
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| Publisher | Japan Society of Circulation Control |
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| Abstract | The purpose of this study was to compare the influence of the anesthetic depth during induced hypotensive anesthesia exerting on the metabolic response when induced hypotensive anesthesia was carried out by using trimethaphan or trinitroglycerin. Dividing the anesthesias for tympanoplasty into nitrous oxide-oxgen (GO) plus 1% halothane under either trimethaphan (TMP-A group) or trinitroglycerin (TNG-A group) and GO plus 0.5% halothane under either trimethaphan (TMP-B group) or trinitroglycerin (TNG-B group), we studied the effects of each anesthesia on metabolic responses. The mean dose of the induced hypotensive anesthetics was 2.05±0.79mg・kg-1・hr-1, 2.96±0.66mg・kg-1・hr-1, 3.21±1.49μg・kg-1・min-1 and 4.95±1.25μg・kg-1・min-1 in group TMP-A, TMP-B, TNG-A and TNG-B, respectively. In the metabolic response during the induced hypotensive anesthesia, lactic acid increased significantly in all groups. Lactic acid pyruvic acid ratio (LIP) did not elevated significantly in TMP-A group, while elevated in the remaining groups and elevated remarkably in TNG-B group. The blood sugar level during the induced hypotensive anesthesia increased more markedly in TNG-A, B groups more than TMP-A, B groups. On the other hand, non-esterified fatty acid (NEFA) during the hypotensive anesthesia increased significantly in TNG-A, B groups, while no change was noted in TMP-A, B groups. It was concluded that the influence of the induced hypotensive anesthesia exerting on the metabolic response is less by TMP than TNG. |
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| Practice | Basic medicine |
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| Keywords | induced hypotensive anesthesia, trimethaphan, trinitroglycerin, metabolic respons, anesthetic depth |
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