Japanese
Titleカテコラミン投与時の心筋カテコラミン摂取の変化―プロプラノロールの影響―
Subtitle原著
Authors土井敏彦, 神山有史, 斎藤隆雄
Authors(kana)
Organization徳島大学医学部麻酔学教室
Journal循環制御
Volume13
Number3
Page477-483
Year/Month1992/
Article原著
Publisher日本循環制御医学会
Abstract「要旨」心筋のカテコラミン(CA)摂取がプロプラノロール(P)投与によりどの様な影響を受けるかを麻酔開胸犬を用い, エピネフリン(E)或いはノルエピネフリン(NE)持続投与下において血行動態と共に検討した. NE投与群ではP投与により動脈血E濃度は有意に上昇した. 冠動静脈較差より求めた心筋E摂取率は, E投与群でも, NE投与群でもP投与によって増加する傾向を示した. これに反して, 心筋NE摂取率はNE投与群でも, E投与群でもP投与によって変化しなかった. 以上の結果から, Pは動脈血E濃度を上昇させ, 心筋摂取率を増加させる可能性はあるが, 影響は小さく, PにはCA摂取阻害薬のような心毒性はないと思われる.
Practice基礎医学・関連科学
KeywordsMyocardial Catecholamine Uptake, Propranolol
English
TitleChange of Myocardial Catecholamine Uptake during Catecholamine Infusion: Effects of Propranolol
Subtitle
AuthorsToshihiko Doi, Arifumi Kohyama, Takao Saito
Authors(kana)
OrganizationDepartment of Anesthesiology,Tokushima University School of Medicine
JournalCirculation Control
Volume13
Number3
Page477-483
Year/Month1992/
ArticleOriginal article
PublisherJapan Society of Circulation Control
AbstractThe effect of propranolol on myocardial catecholamine uptake was evaluated in 18 anesthetized dogs during epinephrine (E) or norepinephrine (NE) infusion. After baseline measurement, E or NE was infused continuously at a rate of 0.1μg・kg-1・min-1. Measurement was then performed at 20 minutes after catecholamine infusion and at 5 minutes after propranolol administration (0.1mg・kg-1). Plasma E and NE concentration of artery and coronary sinus were determined by HPLC-THI method. The myocardial fractional extraction of E was decreased slightly, but not significantly, with E infusion (from 80.2±3.3% to 67.8±5.1%, mean±SE). Propranolol caused slight increase of the fractional extraction of E (70.2±6.0%). Neither E infusion nor propranolol affected the fractional extraction of NE significantly. NE infusion increased the fractional extraction of NE significantly (from 55.7±5.7% to 73.6±2.9%, p<0.05), and decreased the fractional extraction of E significantly (from 81.0±3.1% to 74.1±3.2%, p<0.05). Propranolol caused significant increase of arterial E concentration and tended to increase the fractional extraction of E (78.9±2.8%), but not NE (73.1±4.3%). These results indicate that propranolol caused increase of arterial E concentration, consequently increased myocardial fractional extraction of E without the direct effect on myocardial NE uptake.
PracticeBasic medicine
KeywordsMyocardial Catecholamine Uptake, Propranolol

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